Featured Research

from universities, journals, and other organizations

Researchers find chemical signature for 'fast' form of Parkinson's

Date:
November 22, 2013
Source:
University of California - Los Angeles
Summary:
Scientists have discovered a potential biochemical signal that can predict the progression of the rapid form of Parkinson's disease early-on, right after onset of motor symptoms. The hope is that blood-based biochemical signals such as this may aid in earlier detection and more effective management of the disease.

The physical decline experienced by Parkinson's disease patients eventually leads to disability and a lower quality of life. Depending on the individual, the disorder can progress rapidly or slowly.

Related Articles


Scientists at UCLA and colleagues have now, for the first time, identified a biochemical signal in the blood associated with the faster-progressing form of Parkinson's. Such a biomarker could help doctors predict early on, just after the onset of motor symptoms, how rapidly the disease will progress. The researchers said they hope blood-based biomarkers like this one will aid in earlier detection and lead to more effective disease management.

The research findings appear in the online edition of the journal PLOS ONE.

Parkinson's disease is the second most common neurodegenerative disorder, afflicting more than 1 percent of all people over 60. Besides Parkinson's effects on walking, speaking and other motor functions, the disease also results in cognitive decline and depression. Further, it places a tremendous burden on caregivers and costs the U.S. an estimated $23 billion annually.

"The course of Parkinson's can be highly variable," said Dr. Beate Ritz, professor and chair of the department of epidemiology at UCLA's Fielding School of Public Health and one of the senior authors of the paper. "Some patients can become wheelchair-bound, demented or severely depressed within just a few years after diagnosis, while others are spared for longer periods."

For the study, the researchers initially drew blood samples from 250 Parkinson's patients in the early stages of the disease who were living the Central Valley region of California. These patients were then followed for five to 10 years. Forty of them were identified as having slow-progressing Parkinson's, and 40 had the fast-progressing form of the disease. Blood samples from patients in both groups were compared to samples from a group of 20 healthy individuals from the same area in California.

The researchers used high-resolution mass spectrometry to identify metabolic or chemical fingerprints in the blood. They discovered a potential biomarker for the fast-progressing type of Parkinson's disease. That biomarker, called N8-acetyl spermidine, was significantly elevated in the rapid progressors, compared with both the slow progressors and the healthy control subjects.

"This is an important step forward in understanding how Parkinson's evolves," said Ritz, who holds a joint appointment as a professor in the UCLA Department of Neurology. "Such biomarkers reflecting the pathogenesis of Parkinson's are greatly needed due to the fact that the degeneration of the neurons in the brain that produce dopamine -- a hallmark of Parkinson's disease -- is an irreversible process. In addition, that process begins up to 20 to 30 years before imaging can identify any brain changes.

"Our hope is that such biomarkers may aid in earlier detection and more effective disease management, and that they will lead to new prevention strategies and improved clinical trials for new treatments based on a better understanding of how the disease progresses."


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Journal Reference:

  1. James R. Roede, Karan Uppal, Youngja Park, Kichun Lee, Vilinh Tran, Douglas Walker, Frederick H. Strobel, Shannon L. Rhodes, Beate Ritz, Dean P. Jones. Serum Metabolomics of Slow vs. Rapid Motor Progression Parkinson’s Disease: a Pilot Study. PLoS ONE, 2013; 8 (10): e77629 DOI: 10.1371/journal.pone.0077629

Cite This Page:

University of California - Los Angeles. "Researchers find chemical signature for 'fast' form of Parkinson's." ScienceDaily. ScienceDaily, 22 November 2013. <www.sciencedaily.com/releases/2013/11/131122103938.htm>.
University of California - Los Angeles. (2013, November 22). Researchers find chemical signature for 'fast' form of Parkinson's. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2013/11/131122103938.htm
University of California - Los Angeles. "Researchers find chemical signature for 'fast' form of Parkinson's." ScienceDaily. www.sciencedaily.com/releases/2013/11/131122103938.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins