Featured Research

from universities, journals, and other organizations

Computer models predict how patients respond to HIV drug therapy without HIV genotype

Date:
November 25, 2013
Source:
RDI
Summary:
New computer models predict how patients whose HIV therapy is failing will respond to any new combination of drugs, without the need for an HIV genotype: a test used in wealthy countries to read the genetic code of the virus and help select drugs to which the virus is sensitive. In fact, the models were significantly more accurate predictors of treatment response than the genotype.

New computer models described today in the Journal of Antimicrobial Chemotherapy predict how patients whose HIV therapy is failing will respond to any new combination of drugs, without the need for an HIV genotype: a test used in wealthy countries to read the genetic code of the virus and help select drugs to which the virus is sensitive. In fact, the models were significantly more accurate predictors of treatment response than the genotype.

Related Articles


The HIV Resistance Response Database Initiative (RDI) developed these latest models specifically for use in the many settings where genotyping is unaffordable. They estimate the probability that any combination of HIV drugs will reduce the amount of virus to undetectable levels in patients whose current therapy is failing. They were trained with data from tens of thousands of patients in clinics all over the world, including for the first time, patients from Southern Africa. They were around 80% accurate, which is significantly better than the 57% accuracy achieved by genotyping.

"This study and these models are proof of principle that this could be a very helpful approach for selecting effective therapy in highly resource-constrained settings, such as Southern Africa," commented Professor Robin Wood, Head of the Desmond Tutu HIV Centre, University of Cape Town, South Africa and a co-author on the paper." As more of our patients fail first and even second line therapy, it is critical to optimise the selection from our limited range of drugs to achieve maximum suppression of the virus and this system could be very useful."

The new models are now available to be used by healthcare professionals as part of the RDI's HIV Treatment Response Prediction System (HIV-TRePS), which is freely available online at www.hivrdi.org/treps. The system also enables users to enter the costs of the drugs in their clinic and so model both the cost and the effectiveness of various treatment options. A previous pilot study using data from an HIV clinic in India indicated that the system could identify more effective and less costly combinations of drugs that those actually used in the clinic.

"Currently, most HIV patients in resource-limited settings are treated according to WHO public health guidelines that offer very limited treatment options," explained Dr Hugo Tempelman, Clinical Director of the Ndlovu Care Group, Elandsdoorn, South Africa and co-author on the paper. "The HIV-TRePS system, incorporating these models, enables doctors to tailor the HIV treatment based on the cost and predicted effectiveness of the treatment. What is wonderful is that HIV-TRePS provides us with high predictive value at no cost."

The data required by the system for its predictions includes a measure of the amount of virus in the patient's bloodstream (the viral load), a test that is not widely used in resource-limited settings. However, the potential cost savings offered by the system are likely to cover the costs of viral load testing, many times over. Moreover, viral load monitoring of HIV therapy is now recommended by the World Health Organisation in all settings and initiatives are underway to fund it, including the formation of the Load Zero Foundation, formed specifically with this goal.3

"We are very encouraged by the results with these models." Commented Dr Andrew Revell, Executive Director of the RDI. "They show that not having access to genotyping in resource-limited settings need not be barrier to providing individualised, optimised HIV drug therapy."


Story Source:

The above story is based on materials provided by RDI. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. D. Revell, D. Wang, R. Wood, C. Morrow, H. Tempelman, R. L. Hamers, G. Alvarez-Uria, A. Streinu-Cercel, L. Ene, A. M. J. Wensing, F. DeWolf, M. Nelson, J. S. Montaner, H. C. Lane, B. A. Larder. Computational models can predict response to HIV therapy without a genotype and may reduce treatment failure in different resource-limited settings. Journal of Antimicrobial Chemotherapy, 2013; 68 (6): 1406 DOI: 10.1093/jac/dkt041

Cite This Page:

RDI. "Computer models predict how patients respond to HIV drug therapy without HIV genotype." ScienceDaily. ScienceDaily, 25 November 2013. <www.sciencedaily.com/releases/2013/11/131125091527.htm>.
RDI. (2013, November 25). Computer models predict how patients respond to HIV drug therapy without HIV genotype. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/11/131125091527.htm
RDI. "Computer models predict how patients respond to HIV drug therapy without HIV genotype." ScienceDaily. www.sciencedaily.com/releases/2013/11/131125091527.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins