Featured Research

from universities, journals, and other organizations

Buildup of amyloid in brain blood vessels promotes early cognitive impairment

Date:
November 27, 2013
Source:
Stony Brook Medicine
Summary:
A team of researchers has discovered in a model of Alzheimer’s disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment.

A team of Stony Brook University researchers led by William Van Nostrand, PhD, Professor in the Department of Neurosurgery, has discovered in a model of Alzheimer's disease that early accumulation of a small protein, known as amyloid β, in the blood vessels of the brain can drive early cognitive impairment. The findings, published in the current online edition of the Journal of Alzheimer's Disease, suggest that targeting early buildup of amyloid in brain blood vessels could be a potential treatment strategy in early stage disease.

Alzheimer's disease is a neurodegenerative condition that causes progressive decline in cognitive function. Studies have shown that in Alzheimer's disease and related disorders there is an abnormal accumulation of amyloid in the brain that is believed by researchers to contribute to the dysfunction and eventual death of neuronal cells. When amyloid accumulates and aggregates in the Alzheimer's disease process, amyloid deposits as either structures known as amyloid plaques around neuronal cells or deposits of amyloid in the blood vessels of the brain.

In the research paper, titled "Cerebral Microvascular Rather than Parenchymal Amyloid-β Protein Pathology Promotes Early Cognitive Impairment in Transgenic Mice," the Stony Brook team compared two disease models -- one that developed amyloid plaques and the other that developed cerebral blood vessel amyloid. The team assessed cognitive abilities at intervals and found that at three months, the model with brain blood vessel amyloid were cognitively impaired but the model with amyloid plaques were not cognitively impaired.

"Our results are intriguing because it appears cerebrovascular amyloid rather than amyloid plaques around neuronal cells is an early influence on cognitive decline," said Dr. Van Nostrand. "This opens the door to continued investigation on the role of amyloid on brain blood vessels in the Alzheimer's disease process and could be a first step toward developing more effective treatment targets for the onset of amyloid-associated cognitive impairment based on this particular type of amyloid buildup and associated pathologies."

Interestingly, cognitive impairment in both models became similar at six months, which further suggests that the when amyloid continues to accumulate around neuronal cells and cerebral blood vessels cognitive impairment occurs.

Dr. Van Nostrand cautioned that much more investigation using various comparative amyloid models is necessary before concluding that cerebral blood vessel amyloid is a key treatment target for early disease onset. He added that while amyloid buildup appears to be a pathology associated with Alzheimer's disease, given the complicated disease process, it is not fully known the relative impact of each of these amyloid lesions within the brain on cognitive impairment.


Story Source:

The above story is based on materials provided by Stony Brook Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wenjin Xu, Feng Xu, Maria E. Anderson, Annmarie E. Kotarba, Judianne Davis, John K. Robinson, William E. Van Nostrand. Cerebral Microvascular Rather than Parenchymal Amyloid-β Protein Pathology Promotes Early Cognitive Impairment in Transgenic Mice. Journal of Alzheimer's Disease, November 2013

Cite This Page:

Stony Brook Medicine. "Buildup of amyloid in brain blood vessels promotes early cognitive impairment." ScienceDaily. ScienceDaily, 27 November 2013. <www.sciencedaily.com/releases/2013/11/131127170101.htm>.
Stony Brook Medicine. (2013, November 27). Buildup of amyloid in brain blood vessels promotes early cognitive impairment. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2013/11/131127170101.htm
Stony Brook Medicine. "Buildup of amyloid in brain blood vessels promotes early cognitive impairment." ScienceDaily. www.sciencedaily.com/releases/2013/11/131127170101.htm (accessed October 1, 2014).

Share This



More Mind & Brain News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
Your Spouse's Personality May Influence Your Earnings

Your Spouse's Personality May Influence Your Earnings

Newsy (Sep. 26, 2014) Research from Washington University suggest people with conscientious spouses have greater career success. Video provided by Newsy
Powered by NewsLook.com
Can A Blood Test Predict Psychosis Risk?

Can A Blood Test Predict Psychosis Risk?

Newsy (Sep. 26, 2014) Researchers say certain markers in the blood can predict risk of psychosis later in the life. The test can aid in early treatment for the condition. Video provided by Newsy
Powered by NewsLook.com
Harpist Soothes Gorillas, Orangutans With Music

Harpist Soothes Gorillas, Orangutans With Music

AP (Sep. 25, 2014) Teri Tacheny, a harpist, has a loyal following of fans who appreciate her soothing music. Every month, gorillas, orangutans and monkeys amble down to hear her play at the Como Park Zoo in Minnesota. (Sept. 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins