Featured Research

from universities, journals, and other organizations

First Nations adults have more than double risk of end-stage kidney disease

Date:
December 2, 2013
Source:
Canadian Medical Association Journal
Summary:
First Nations adults with diabetes have more than double the risk of end-stage kidney disease compared with non–First Nations adults, found a new study.

First Nations adults with diabetes have more than double the risk of end-stage kidney disease compared with non-First Nations adults, found a new study in CMAJ (Canadian Medical Association Journal).

Diabetes and high blood pressure are common causes of kidney disease, which can result in end-stage renal disease after years of slow decline in kidney function.

To understand the high rates of end-stage renal disease in First Nations people, researchers looked at all cases of diabetes over 25 years (from 1980 to 2005) in the Canadian province of Saskatchewan. There were 8254 First Nations patients with diabetes whose mean age at diagnosis was 47.2 years; in non-First Nations adults (82 175 people), diabetes was diagnosed at a much older age, with a mean age of 61.6 years. More than 82% of First Nations people had diabetes before age 60, whereas most non-First Nations (56%) were over age 60.

"Because they are younger than non-First Nations individuals when diabetes first develops, First Nations individuals are more likely to survive long enough for end-stage renal disease to occur, presumably because of lower cardiovascular mortality," writes Dr. Roland Dyck, a professor with the departments of Community Health and Epidemiology, and Medicine, University of Saskatchewan, with coauthors.

End-stage renal disease occurred in 2.4% (200) of First Nations people, and 18% (1482) died without end-stage renal disease. In comparison, only 0.7% of non-First Nations people had end-stage renal disease, and 34.6% (28 450) died from other diabetes-related complications. Men were 50% more likely than women to have end-stage renal disease.

"The implications of our findings are sobering," write the authors. "Among First Nations adults, type 2 diabetes is increasingly occurring during younger decades of life. Among First Nations children, the prevalence of diabetes tripled between 1980 and 2005, and the offspring of these individuals are in turn experiencing an even higher risk of childhood type 2 diabetes. …Without substantial improvements in the prevention and treatment of this disease, this pattern will likely translate into increasing numbers of First Nations people with diabetes-related end-stage renal disease and possibly other chronic diabetic complications."

The authors recommend focusing on prevention strategies to reduce the number of new cases of diabetes and to help delay the onset of diabetes.

"For clinicians and administrators, [the] data indicate that the risk of renal disease increases progressively with increasing age. With the onset of diabetes at a younger age among First Nations people, end-stage renal disease is thus a common outcome," writes Dr. Stephen McDonald, School of Medicine, University of Adelaide, Australia, in a linked commentary. "The challenge is not only to provide effective renal replacement therapy, but also to implement more effective primary prevention initiatives to delay the onset of diabetes and the progression of chronic kidney disease."

In a related paper in CMAJ, Alberta researchers found that rates of kidney disease are two to three times higher in First Nations people than in non-First Nations people. However, the association of albuminuria -- the secretion of the protein albumin in urine, which indicates kidney problems -- is similar in both First Nations and non-First Nations people.

"Despite as higher prevalence of heavy albuminuria among First Nations people, we did not find that the presence or severity of albuminuria conferred an additional risk to the development of kidney failure," writes Dr. Brenda Hemmelgarn, Department of Community Health Sciences, University of Calgary, with coauthors. "Even among participants with no measure of albuminuria, risk of progression to kidney failure was similarly elevated for First Nations compared with non-First Nations participants within each category of estimated GFR [glomerular filtration rate]."


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ying Jiang, Nathaniel Osgood, Hyun-Ja Lim, Mary Rose Stang, and Roland Dyck. Differential mortality and the excess burden of end-stage renal disease among First Nations people with diabetes mellitus: a competing-risks analysis. CMAJ, December 2013

Cite This Page:

Canadian Medical Association Journal. "First Nations adults have more than double risk of end-stage kidney disease." ScienceDaily. ScienceDaily, 2 December 2013. <www.sciencedaily.com/releases/2013/12/131202121455.htm>.
Canadian Medical Association Journal. (2013, December 2). First Nations adults have more than double risk of end-stage kidney disease. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2013/12/131202121455.htm
Canadian Medical Association Journal. "First Nations adults have more than double risk of end-stage kidney disease." ScienceDaily. www.sciencedaily.com/releases/2013/12/131202121455.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins