Featured Research

from universities, journals, and other organizations

Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring

Date:
December 8, 2013
Source:
American Epilepsy Society (AES)
Summary:
Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur. A frequently asked question in clinical practice concerns the safety and long-term effect of AED withdrawal or discontinuation in this diagnostic procedure.

Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur. A frequently asked question in clinical practice concerns the safety and long-term effect of AED withdrawal or discontinuation in this diagnostic procedure.

To answer this question, investigators at the University of Saskatchewan in Canada, conducted a prospective study of 150 patients admitted to their vEEG telemetry unit over a period of five years. The patients' medication therapy was discontinued by a standardized rapid AED withdrawal protocol. Rapid discontinuation was not done in patients with a previous history of status epilepticus or taking phenobarbital. The researchers then assessed the number of patients having subsequent seizures, the safety of the withdrawal/ telemetry procedure, and epilepsy surgery outcome.

Seizures and non-epileptic events were recorded in nearly 90% of the patients. This diagnostic yield was achieved over a mean VEM duration of 4.53 days, with no benefit of longer monitoring. Habitual seizures were recorded in 107 patients to support a diagnosis of epilepsy while non-epileptic events were recorded in 36 patients.

Based on the information provided by vEEG telemetry, 52 of 158 patients (32.9%) received epilepsy surgery of which nearly 90% attained Engel Class I/II status at 24 months. The complication rate was 5.06%, characterized largely by musculoskeletal pain secondary to clinical seizure activity, with no mortality observed. In the first month following VEM 2.5% of patients received emergency-room admission for seizure clustering.

"VEEG telemetry monitoring with early cessation of AED therapy is safe and effective," says Syed A. RIzvi, MD, lead author of the report, "Surgical outcomes are favorable and support the use of this technique under the supervision of a team comprising epileptologists, nurses, and EEG technologists."


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring." ScienceDaily. ScienceDaily, 8 December 2013. <www.sciencedaily.com/releases/2013/12/131208090246.htm>.
American Epilepsy Society (AES). (2013, December 8). Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2013/12/131208090246.htm
American Epilepsy Society (AES). "Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring." ScienceDaily. www.sciencedaily.com/releases/2013/12/131208090246.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins