Featured Research

from universities, journals, and other organizations

Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring

Date:
December 8, 2013
Source:
American Epilepsy Society (AES)
Summary:
Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur. A frequently asked question in clinical practice concerns the safety and long-term effect of AED withdrawal or discontinuation in this diagnostic procedure.

Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur. A frequently asked question in clinical practice concerns the safety and long-term effect of AED withdrawal or discontinuation in this diagnostic procedure.

Related Articles


To answer this question, investigators at the University of Saskatchewan in Canada, conducted a prospective study of 150 patients admitted to their vEEG telemetry unit over a period of five years. The patients' medication therapy was discontinued by a standardized rapid AED withdrawal protocol. Rapid discontinuation was not done in patients with a previous history of status epilepticus or taking phenobarbital. The researchers then assessed the number of patients having subsequent seizures, the safety of the withdrawal/ telemetry procedure, and epilepsy surgery outcome.

Seizures and non-epileptic events were recorded in nearly 90% of the patients. This diagnostic yield was achieved over a mean VEM duration of 4.53 days, with no benefit of longer monitoring. Habitual seizures were recorded in 107 patients to support a diagnosis of epilepsy while non-epileptic events were recorded in 36 patients.

Based on the information provided by vEEG telemetry, 52 of 158 patients (32.9%) received epilepsy surgery of which nearly 90% attained Engel Class I/II status at 24 months. The complication rate was 5.06%, characterized largely by musculoskeletal pain secondary to clinical seizure activity, with no mortality observed. In the first month following VEM 2.5% of patients received emergency-room admission for seizure clustering.

"VEEG telemetry monitoring with early cessation of AED therapy is safe and effective," says Syed A. RIzvi, MD, lead author of the report, "Surgical outcomes are favorable and support the use of this technique under the supervision of a team comprising epileptologists, nurses, and EEG technologists."


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring." ScienceDaily. ScienceDaily, 8 December 2013. <www.sciencedaily.com/releases/2013/12/131208090246.htm>.
American Epilepsy Society (AES). (2013, December 8). Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2013/12/131208090246.htm
American Epilepsy Society (AES). "Researchers report on safety of rapid AED withdrawal in pre-surgical monitoring." ScienceDaily. www.sciencedaily.com/releases/2013/12/131208090246.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins