Featured Research

from universities, journals, and other organizations

New type of immune cell discovered that helps tumors to grow

Date:
December 10, 2013
Source:
University of New Mexico Cancer Center
Summary:
A cross-institutional, international team of scientists recently discovered a new, important step of the process that grows new blood vessels, a discovery that could lead to a new way to combat cancer.

One way to defeat an opponent is to cut off its supply lines. Tumors are no different. The supply lines for tumors are the blood vessels that ferry oxygen and nutrients to the cells. Restricting the blood vessels that feed tumor cells can shrink the tumor. A cross-institutional international team of scientists recently discovered a new, important step of the process that grows new blood vessels, a discovery that could lead to a new way to combat cancer.

Wadih Arap, MD, PhD, and Renata Pasqualini, PhD, now at the University of New Mexico Cancer Center, are the leaders of the team of scientists that recently discovered a new type of immune cell called "CD13+ myeloid cells." These cells gather around tumors and release an enzyme called CD13. The team's previous studies showed that CD13 spurs a natural process called angiogenesis, which grows new blood vessels, and they report identification of the cell that makes the CD13 in their new study recently published in the "Proceedings of the National Academy of Sciences."

Dr. Arap is the Deputy Director at the UNM Cancer Center and a UNM Professor and Division Chief of Hematology/Oncology, in the Department of Internal Medicine at the UNM School of Medicine. His wife, Dr. Pasqualini, is also a UNM Professor and is the Chief of the Division of Molecular Medicine in the Department of Internal Medicine. They are experts in vascular biology -- the study of blood vessels -- and in drug development. The discovery of CD13+ myeloid cells as part of the complex process of angiogenesis could make them a possible target in disrupting a cancer tumor's supply line.

Says Dr. Pasqualini, "the far-reaching biological principle emphasized in this study is that the several types of cells in a given normal or pathological organ are highly interactive. They receive and deliver molecular signals with their neighbors, such that each of them appears to be unable to sustain its usual functions in isolation." "These findings could have relevance also for bone metastasis or other cancers featuring angiogenesis (such as multiple myeloma, a blood cell cancer in which there is prominent angiogenesis in the bone marrow itself)," says Angelo Corti, one of the co-authors. "CD13+ bone marrow-derived cells residing in the marrow might contribute strongly to angiogenesis in this context."

Co-author Richard Sidman adds, "Tumor cells depend for their nutrition and growth on blood that reaches them through vessels composed of several types of cells, but also, as is less commonly recognized, on interactions of cancer and blood vessel cells with special types of non-tumor cells that are formed in the bone marrow. These cells migrate through the blood to populate the cancer tissue, where their direct interplay promotes the cancer cells to grow and even to metastasize. We identify in this paper a previously unknown subclass of these bone marrow-derived cells that represent new plausible targets for anti-cancer therapy."

Paper reference "CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis" was published online, ahead of print, on Dec 2nd 2013 in PNAS. Authors include: Renata Pasqualini (now at the UNM Cancer Center, formerly at the David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston); Wadih Arap (now at the UNM Cancer Center, formerly at the David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston); Eleanora Dondossola (David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston); Angelo Corti (San Raffaele Scientific Institute, Milan, Italy); and, Richard Sidman (Harvard Medical School and Beth Israel-Deaconess Medical Center, Boston).


Story Source:

The above story is based on materials provided by University of New Mexico Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Renata Pasqualini, PhD, Wadih Arap, MD, PhD et al. CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis. PNAS, December 2013

Cite This Page:

University of New Mexico Cancer Center. "New type of immune cell discovered that helps tumors to grow." ScienceDaily. ScienceDaily, 10 December 2013. <www.sciencedaily.com/releases/2013/12/131210113319.htm>.
University of New Mexico Cancer Center. (2013, December 10). New type of immune cell discovered that helps tumors to grow. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2013/12/131210113319.htm
University of New Mexico Cancer Center. "New type of immune cell discovered that helps tumors to grow." ScienceDaily. www.sciencedaily.com/releases/2013/12/131210113319.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins