Featured Research

from universities, journals, and other organizations

Study analyzes diabetes drug metformin as obesity treatment for children

Date:
December 16, 2013
Source:
The JAMA Network Journals
Summary:
Treatment with the diabetes drug metformin appears to be associated with a modest reduction in body mass index in obese children when combined with lifestyle interventions such as diet and exercise.

Treatment with the diabetes drug metformin appears to be associated with a modest reduction in body mass index (BMI) in obese children when combined with lifestyle interventions such as diet and exercise, according to a study by Marian S. McDonagh, Pharm. D., of the Oregon Health & Science University, and colleagues.

Related Articles


Childhood obesity is a health problem in the United States, with nearly 17 percent of children being obese. Metformin is approved by the Food and Drug Administration to treat type 2 diabetes in adults and children over 10 years old, but it has been used off-label in recent years to treat childhood obesity.

Researchers assessed the safety and effectiveness of metformin to treat obesity in children (ages 18 and younger) without a diagnosis of diabetes by reviewing results from 14 clinical trials. The trials included 946 children and adolescents, who ranged in age from 10 to 16 years, and had baseline BMIs from 26 to 41.

The results indicated that while metformin helped obese children reduce their BMI (a reduction of -1.38 from baseline) and weight compared with lifestyle interventions alone, the change was small compared to what is needed for long-term health benefits. Researchers noted no serious adverse events were reported.

"While our results indicate that some obese children and adolescents may benefit from short-term treatment with metformin combined with lifestyle interventions, these benefits were very modest, not achieving a 5 percent reduction in BMI," the study concludes.


Story Source:

The above story is based on materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marian S. McDonagh, Shelley Selph, Alp Ozpinar, Carolyn Foley. Systematic Review of the Benefits and Risks of Metformin in Treating Obesity in Children Aged 18 Years and Younger. JAMA Pediatrics, 2013; DOI: 10.1001/jamapediatrics.2013.4200

Cite This Page:

The JAMA Network Journals. "Study analyzes diabetes drug metformin as obesity treatment for children." ScienceDaily. ScienceDaily, 16 December 2013. <www.sciencedaily.com/releases/2013/12/131216183851.htm>.
The JAMA Network Journals. (2013, December 16). Study analyzes diabetes drug metformin as obesity treatment for children. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/12/131216183851.htm
The JAMA Network Journals. "Study analyzes diabetes drug metformin as obesity treatment for children." ScienceDaily. www.sciencedaily.com/releases/2013/12/131216183851.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins