Featured Research

from universities, journals, and other organizations

Study analyzes diabetes drug metformin as obesity treatment for children

Date:
December 16, 2013
Source:
The JAMA Network Journals
Summary:
Treatment with the diabetes drug metformin appears to be associated with a modest reduction in body mass index in obese children when combined with lifestyle interventions such as diet and exercise.

Treatment with the diabetes drug metformin appears to be associated with a modest reduction in body mass index (BMI) in obese children when combined with lifestyle interventions such as diet and exercise, according to a study by Marian S. McDonagh, Pharm. D., of the Oregon Health & Science University, and colleagues.

Childhood obesity is a health problem in the United States, with nearly 17 percent of children being obese. Metformin is approved by the Food and Drug Administration to treat type 2 diabetes in adults and children over 10 years old, but it has been used off-label in recent years to treat childhood obesity.

Researchers assessed the safety and effectiveness of metformin to treat obesity in children (ages 18 and younger) without a diagnosis of diabetes by reviewing results from 14 clinical trials. The trials included 946 children and adolescents, who ranged in age from 10 to 16 years, and had baseline BMIs from 26 to 41.

The results indicated that while metformin helped obese children reduce their BMI (a reduction of -1.38 from baseline) and weight compared with lifestyle interventions alone, the change was small compared to what is needed for long-term health benefits. Researchers noted no serious adverse events were reported.

"While our results indicate that some obese children and adolescents may benefit from short-term treatment with metformin combined with lifestyle interventions, these benefits were very modest, not achieving a 5 percent reduction in BMI," the study concludes.


Story Source:

The above story is based on materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marian S. McDonagh, Shelley Selph, Alp Ozpinar, Carolyn Foley. Systematic Review of the Benefits and Risks of Metformin in Treating Obesity in Children Aged 18 Years and Younger. JAMA Pediatrics, 2013; DOI: 10.1001/jamapediatrics.2013.4200

Cite This Page:

The JAMA Network Journals. "Study analyzes diabetes drug metformin as obesity treatment for children." ScienceDaily. ScienceDaily, 16 December 2013. <www.sciencedaily.com/releases/2013/12/131216183851.htm>.
The JAMA Network Journals. (2013, December 16). Study analyzes diabetes drug metformin as obesity treatment for children. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/12/131216183851.htm
The JAMA Network Journals. "Study analyzes diabetes drug metformin as obesity treatment for children." ScienceDaily. www.sciencedaily.com/releases/2013/12/131216183851.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins