Featured Research

from universities, journals, and other organizations

MRI method for measuring MS progression validated

Date:
December 19, 2013
Source:
University of Western Ontario
Summary:
New imaging research has demonstrated that a magnetic resonance imaging approach called quantitative susceptibility mapping can be an important tool for diagnosing and tracking the progression of Multiple Sclerosis and other neurological diseases.

New imaging research from Western University (London, Canada) has demonstrated that a magnetic resonance imaging (MRI) approach called quantitative susceptibility mapping (QSM) can be an important tool for diagnosing and tracking the progression of Multiple Sclerosis (MS) and other neurological diseases. QSM provides a quantitative way to measure myelin content and iron deposition in the brain -important factors in the physiology of MS. The research led by Ravi Menon, PhD, a scientist at Western's Robarts Research Institute, is published in this week's Proceedings of the National Academy of Sciences (PNAS).

Related Articles


Menon and his associates including first author David Rudko, set out to determine whether QSM was indeed quantitative. Interpretation of QSM data requires the use of a model of the underlying tissue structure. The scientists found that the most common approach to creating QSM images was in fact insufficient to generate quantitative images -- that is images in which myelin content and iron can be measured. They demonstrated this by exploring the orientation dependence of the MRI signal. This particular signal has generally thought to be a constant, but the team showed that it depends on tissue orientation in both cortical grey and white matter, but not in the deep brain structures such as the basal ganglia. All these areas are implicated in MS.

They demonstrated the discordance between the models for QSM using a device that rotated a rat's brain so that it could be scanned from 18 different angles, using a 9.4 T MRI. The brains were then sent to histology for comparison. They found the values depended on the microstructure of the brain such as myelin concentration and integrity, and iron deposition. The study also showed, for the first time, the correlation between MRI measurement and histology measurement when the correct model was used.

"With this methodology, we now have a quantitative way to interpret myelin and iron concentrations, and in particular, any changes to them over time," says Menon, who holds a Canada Research Chair in Functional Magnetic Resonance Imaging. "We've been doing these scans on MS patients for a while, but nobody knew if it was a valid approach or not. We now know how to interpret the data. It allows us to separate changes in white matter degeneration, from other changes such as iron deposition, which in conventional imaging all looks the same."

Menon says the next step is to use this new imaging approach to study the changes that occur in MS and to find out if it is predictive of disease progression.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Journal Reference:

  1. David A. Rudko et al. Origins of R2 orientation dependence in gray and white matter. PNAS, December 2013

Cite This Page:

University of Western Ontario. "MRI method for measuring MS progression validated." ScienceDaily. ScienceDaily, 19 December 2013. <www.sciencedaily.com/releases/2013/12/131219130929.htm>.
University of Western Ontario. (2013, December 19). MRI method for measuring MS progression validated. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/12/131219130929.htm
University of Western Ontario. "MRI method for measuring MS progression validated." ScienceDaily. www.sciencedaily.com/releases/2013/12/131219130929.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins