Featured Research

from universities, journals, and other organizations

Researchers find potential new treatment approach for pancreatic cancer

Date:
December 20, 2013
Source:
University of Manchester
Summary:
Scientists believe they have discovered a new way to make chemotherapy treatment more effective for pancreatic cancer patients. Pancreatic cancer is an aggressive cancer with poor prognosis and limited treatment options and is highly resistant to chemotherapy and radiotherapy.

Scientists from The University of Manchester -- part of Manchester Cancer Research Centre believe they have discovered a new way to make chemotherapy treatment more effective for pancreatic cancer patients.

Related Articles


Pancreatic cancer is an aggressive cancer with poor prognosis and limited treatment options and is highly resistant to chemotherapy and radiotherapy.

But researchers believe they have found an effective strategy for selectively killing pancreatic cancer while sparing healthy cells which could make treatment more effective.

Dr Jason Bruce, from the Physiological Systems and Disease Research Group, who led the research, said: "Pancreatic cancer is one of the most aggressive and deadly cancers. Most patients develop symptoms after the tumour has spread to other organs. To make things worse, pancreatic cancer is highly resistant to chemotherapy and radiotherapy. Clearly a radical new approach to treatment is urgently required. We wanted to understand how the switch in energy supply in cancer cells might help them survive."

The research, published in The Journal of Biological Chemistry this month, found pancreatic cancer cells may have their own specialised energy supply that maintains calcium levels and keeps cancer cells alive.

Maintaining a low concentration of calcium within cells is vital to their survival and this is achieved by calcium pumps on the plasma membrane.

This calcium pump, known as PMCA, is fuelled using ATP -- the key energy currency for many cellular processes.

All cells generate energy from nutrients using two major biochemical energy "factories," mitochondria and glycolysis. Mitochondria generate approximately 90% of the cells' energy in normal healthy cells. However, in pancreatic cancer cells there is a shift towards glycolysis as the major energy source. It is thought that the calcium pump may have its own supply of glycolytic ATP, and it is this fuel supply that gives cancer cells a survival advantage over normal cells.

Scientists used cells taken from human tumours and looked at the effect of blocking each of these two energy sources in turn.

Their study, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), National Institute of Health Research (NIHR) Biomedical Research Centre and AstraZeneca, shows that blocking mitochondrial metabolism had no effect. However, when they blocked glycolysis, they saw a reduced supply of ATP which inhibited the calcium pump, resulting in a toxic calcium overload and ultimately cell death.

Dr Bruce added: "It looks like glycolysis is the key process in providing ATP fuel for the calcium pump in pancreatic cancer cells. Although an important strategy for cell survival, it may also be their major weakness.

"Designing drugs to cut off this supply to the calcium pumps might be an effective strategy for selectively killing cancer cells while sparing normal cells within the pancreas."

Maggie Blanks, CEO of the national charity, the Pancreatic Cancer Research Fund said: "These findings will certainly of great interest to the pancreatic cancer research community and we'd be keen to see how this approach progresses. Finding weaknesses that can be exploited in this highly aggressive cancer is paramount, so we want to congratulate the Manchester team for their discovery."


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew D. James; Oihane Erice; Jason I. E. Bruce. Glycolytic ATP Fuels the Plasma Membrane Calcium Pump Critical for Pancreatic Cancer Cell Survival. The Journal of Biological Chemistry, December 2013

Cite This Page:

University of Manchester. "Researchers find potential new treatment approach for pancreatic cancer." ScienceDaily. ScienceDaily, 20 December 2013. <www.sciencedaily.com/releases/2013/12/131220143526.htm>.
University of Manchester. (2013, December 20). Researchers find potential new treatment approach for pancreatic cancer. ScienceDaily. Retrieved December 28, 2014 from www.sciencedaily.com/releases/2013/12/131220143526.htm
University of Manchester. "Researchers find potential new treatment approach for pancreatic cancer." ScienceDaily. www.sciencedaily.com/releases/2013/12/131220143526.htm (accessed December 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Weirdest Health Studies Of 2014

The Weirdest Health Studies Of 2014

Newsy (Dec. 27, 2014) One of this year's strangest studies found people prefer painful electric shocks to being alone with their thoughts. Video provided by Newsy
Powered by NewsLook.com
Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Newsy (Dec. 26, 2014) If patients had led healthier lifestyles, Cancer Research UK found about 40 percent of cancer cases could have been prevented. Video provided by Newsy
Powered by NewsLook.com
When Healthy Eating Becomes Dangerous

When Healthy Eating Becomes Dangerous

Newsy (Dec. 26, 2014) Experts say fad diets can lead to orthorexia, a disorder that can cause physical and emotional distress. Video provided by Newsy
Powered by NewsLook.com
FDA Issues New Warning About Pure Caffeine Powder Usage

FDA Issues New Warning About Pure Caffeine Powder Usage

Newsy (Dec. 24, 2014) The FDA cites two deaths this year linked to pure caffeine powder as warnings of the potentially fatal substance. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins