Featured Research

from universities, journals, and other organizations

Nano-capsules show potential for more potent chemoprevention

Date:
January 8, 2014
Source:
Emory Health Sciences
Summary:
Researchers using nano-capsules made of a water-soluble polymer to deliver the naturally occurring antioxidant, luteolin, were able to inhibit growth of lung cancer and head and neck cancer cells in mice.

Researchers at the Winship Cancer Institute of Emory University have discovered a more effective drug delivery system using nanotechnology that could one day significantly affect cancer prevention.

The study, published today in Cancer Prevention Research, a journal of the American Association for Cancer Research, involved the use of microscopic amounts of the naturally occurring antioxidant, luteolin, that were encapsulated in a water-soluble polymer. When injected into mice the nano-luteolin inhibited growth of lung cancer and head and neck cancer cells.

"Our results suggest that nanoparticle delivery of naturally occurring dietary agents like luteolin has many advantages," says senior study author Dong Moon Shin, MD, professor of hematology and medical oncology at Emory University School of Medicine and associate director of academic development at Winship Cancer Institute. "By using a high concentration of luteolin in the blood, we were better able to inhibit the growth of cancer cells."

Luteolin is known for its anti-inflammatory and anti-cancer effects. It is naturally found in green vegetables such as broccoli, celery and artichokes, however, Shin says large quantities would need to be consumed to be effective. By concentrating the compound into a nanoparticle and making it easy to dissolve in water, researchers conclude nano-luteolin has immense potential for future human studies of chemoprevention

Chemoprevention is currently used to help stop the recurrence of cancer in patients and reduce the risk of cancer in others.


Story Source:

The above story is based on materials provided by Emory Health Sciences. The original article was written by Judy Fortin. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Majumdar, K.-H. Jung, H. Zhang, S. Nannapaneni, X. Wang, A. R. M. R. Amin, Z. Chen, Z. . Chen, D. M. Shin. Luteolin Nanoparticle in Chemoprevention: In Vitro and In Vivo Anticancer Activity. Cancer Prevention Research, 2014; 7 (1): 65 DOI: 10.1158/1940-6207.CAPR-13-0230

Cite This Page:

Emory Health Sciences. "Nano-capsules show potential for more potent chemoprevention." ScienceDaily. ScienceDaily, 8 January 2014. <www.sciencedaily.com/releases/2014/01/140108081219.htm>.
Emory Health Sciences. (2014, January 8). Nano-capsules show potential for more potent chemoprevention. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140108081219.htm
Emory Health Sciences. "Nano-capsules show potential for more potent chemoprevention." ScienceDaily. www.sciencedaily.com/releases/2014/01/140108081219.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins