Featured Research

from universities, journals, and other organizations

Researchers report new method to detect key indicator of heart diseases

Date:
January 16, 2014
Source:
Dartmouth College
Summary:
A team of researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

A team that includes Dartmouth College researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

The results, which appear in the journal Analytical Chemistry, may eventually help to diagnose these conditions earlier on and to provide real-time monitoring of cardiolipin levels.

Cardiolipin is a unique lipid of mitochondria, the cell structures that generate energy. Cardiolipin is important for mitochondrial function in both respiration and apoptosis (programmed cell death). This lipid is an important indicator for cardiac diseases, Barth syndrome and Tangier disease and has been linked to neurodegenerative diseases, HIV and cancers.

Scientific interest in cardiolipin has grown dramatically in the recent years because of the critical role of this lipid in apoptosis and its potential in medical diagnosis. But routine cardiolipin analysis has had to rely on 10-nonyl acridine orange (NAO), the only dye available for cardiolipin detection. The dye, however, has many drawbacks in terms of selectivity and sensitivity.

In their new study, researchers report a new fluorescent compound, TTAPE-Me, that acts as a turn-on sensor for cardiolipin, helping to detect it and determine its amount more effectively than NAO.


Story Source:

The above story is based on materials provided by Dartmouth College. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chris W. T. Leung, Yuning Hong, Jonas Hanske, Engui Zhao, Sijie Chen, Ekaterina V. Pletneva, Ben Zhong Tang. Superior Fluorescent Probe for Detection of Cardiolipin. Analytical Chemistry, 2013; 131227115102009 DOI: 10.1021/ac403616c

Cite This Page:

Dartmouth College. "Researchers report new method to detect key indicator of heart diseases." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116131001.htm>.
Dartmouth College. (2014, January 16). Researchers report new method to detect key indicator of heart diseases. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/01/140116131001.htm
Dartmouth College. "Researchers report new method to detect key indicator of heart diseases." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116131001.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins