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Researchers report new method to detect key indicator of heart diseases

Date:
January 16, 2014
Source:
Dartmouth College
Summary:
A team of researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

A team that includes Dartmouth College researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

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The results, which appear in the journal Analytical Chemistry, may eventually help to diagnose these conditions earlier on and to provide real-time monitoring of cardiolipin levels.

Cardiolipin is a unique lipid of mitochondria, the cell structures that generate energy. Cardiolipin is important for mitochondrial function in both respiration and apoptosis (programmed cell death). This lipid is an important indicator for cardiac diseases, Barth syndrome and Tangier disease and has been linked to neurodegenerative diseases, HIV and cancers.

Scientific interest in cardiolipin has grown dramatically in the recent years because of the critical role of this lipid in apoptosis and its potential in medical diagnosis. But routine cardiolipin analysis has had to rely on 10-nonyl acridine orange (NAO), the only dye available for cardiolipin detection. The dye, however, has many drawbacks in terms of selectivity and sensitivity.

In their new study, researchers report a new fluorescent compound, TTAPE-Me, that acts as a turn-on sensor for cardiolipin, helping to detect it and determine its amount more effectively than NAO.


Story Source:

The above story is based on materials provided by Dartmouth College. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chris W. T. Leung, Yuning Hong, Jonas Hanske, Engui Zhao, Sijie Chen, Ekaterina V. Pletneva, Ben Zhong Tang. Superior Fluorescent Probe for Detection of Cardiolipin. Analytical Chemistry, 2013; 131227115102009 DOI: 10.1021/ac403616c

Cite This Page:

Dartmouth College. "Researchers report new method to detect key indicator of heart diseases." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116131001.htm>.
Dartmouth College. (2014, January 16). Researchers report new method to detect key indicator of heart diseases. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2014/01/140116131001.htm
Dartmouth College. "Researchers report new method to detect key indicator of heart diseases." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116131001.htm (accessed April 19, 2015).

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