Featured Research

from universities, journals, and other organizations

Modified proteins as vaccines against peach allergy

Date:
January 20, 2014
Source:
Universidad Politécnica de Madrid
Summary:
Research has been conducted on the peach allergy, the most common food allergy, and the Pru p 3 protein. As a result of this research work, three hypoallergenic variants of this protein have been developed, including a potential vaccine.

A research conducted by the Centre for Plant Biotechnology and Genomics (UPM-INIA) and led by Araceli Díaz Perales has studied the allergy to peach, the most common food allergy, and the Pru p 3 protein. As a result of this research work, they have developed three hypoallergenic variants of this protein. All can be good candidates for the usage of specific immunotherapy for peach allergy and also can be used as a vaccine.

Nowadays, allergy affects over 25% of the population of developed countries. Currently, the treatment of food allergy consists of avoiding the intake of the food causing the allergy. However, the possibility of cross-reactivity (reaction to related food) might be ineffective.

The specific immunotherapy is the only treatment to prevent more severe signs of allergy progression. Immunotherapy consists of the intake of growing doses of allergen extracts in affected patients. However, the use of this extract could induce anaphylactic reactions or lead to sensitization to new allergens found in the mixture of allergen extracts. According to this, the usage of hypoallergenic molecules (with lower ability of binding antibodies) but with the ability to stimulate the immune system, would be a useful tool for immunotherapy.

The most common food allergy in Spain and the Mediterranean areas is the peach allergy which is mainly caused by the Pru p 3 proteins. The current treatment of this allergy consists of avoiding peach consumption, neither fresh nor processed peaches (juices jam). As an alternative, this allergy research has defined the regions of this allergenic protein that is involved in the antibody binding and the stimulation of the immune system cells. After that, researchers developed three hypoallergenic variants of this protein that can be used as a vaccine.

These variants are the result of modifying epitopes (regions of binding antibodies) of this protein and they were used in a research with patient allergic to peach in order to confirm its capacity as immune system stimulation. Each variant has a different modification that was designed by using genetic tools. Although the 1 variant (Pru p 3.01) showed quite similar allergenic activity with the natural protein, the variants Pru p 3.02 and Pru p 3.03 presented lower capacity for binding antibodies. Also, it maintained its ability to stimulate immune system cells (lymphocytes) of the patients allergic to peach during the in vitro trials.

The results show that these two molecules (Pru p 3.02 and Pru p 3.03) could be good candidates for the usage of specific immunotherapy for allergy to peach.

This research work has established the basis to set a new immunotherapy strategy although it would be required further trials of these two molecules with animal to verify its effectiveness in the treatment for allergy to peach.


Story Source:

The above story is based on materials provided by Universidad Politécnica de Madrid. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Gómez-Casado, M. Garrido-Arandia, P. Gamboa, N. Blanca-López, G. Canto, J. Varela, J. Cuesta-Herranz, L. F. Pacios, A. Díaz-Perales, L. Tordesillas. Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines. Clinical and Developmental Immunology, 2013; 2013: 1 DOI: 10.1155/2013/385615

Cite This Page:

Universidad Politécnica de Madrid. "Modified proteins as vaccines against peach allergy." ScienceDaily. ScienceDaily, 20 January 2014. <www.sciencedaily.com/releases/2014/01/140120090426.htm>.
Universidad Politécnica de Madrid. (2014, January 20). Modified proteins as vaccines against peach allergy. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/01/140120090426.htm
Universidad Politécnica de Madrid. "Modified proteins as vaccines against peach allergy." ScienceDaily. www.sciencedaily.com/releases/2014/01/140120090426.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins