Featured Research

from universities, journals, and other organizations

Depression higher than previously reported in people with severe rheumatoid arthritis

Date:
January 21, 2014
Source:
University of Manchester
Summary:
Levels of depression and anxiety in people with severe rheumatoid arthritis are higher than previously reported, according to new research. As a result of their findings, a multi-center team says that patients with severe active disease, who are waiting to go onto a biological therapy, should be routinely screened for depression by their doctors.

As a result of their findings, a multi-center team led by researchers at the Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester, say that patients with severe active disease, who are waiting to go onto a biological therapy, should be routinely screened for depression by their doctors.

The team, led by Professor Anne Barton, part of the National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit theme lead, also suggest that the way that disease activity in rheumatoid arthritis is currently recorded should be changed in order to improve the way that patients are managed. Their findings are published in the journal Arthritis Care and Research.

Rheumatoid arthritis is a serious, inflammatory, auto-immune condition that affects the joints and the body's internal organs leading to chronic pain and fatigue. New biological therapies have transformed the treatment of people with severe disease in the past decade, although some patients do not adequately respond to these drugs.

The team carried out an observational study of 322 patients with severe rheumatoid arthritis who were waiting to go on biologic therapy.

The aim of the study was to investigate the impact of psychological factors upon each of the different parts of the current measure of disease called the DAS28. The DAS28 score takes into account the number of tender and swollen joints and the level of inflammation in the body. It also includes a subjective, patient-reported measure based on how well the patient is feeling.

The team found that subjective measures of response were more likely to be influenced by psychological factors such as mood or beliefs about their illness and the therapies used.

"This may seem obvious but has not been reported before and is important because without treating the depression, the patient's DAS28 score might not improve as much as it should on a biological drug, and doctors may assume the drug is ineffective," explained Dr Lis Cordingley, a health psychologist who was the lead author on the paper.

Professor Barton added: "This is the first study of its kind in patients with high levels of active disease, and suggests that routinely assessing a patient's moods and beliefs -- separate to their physical state -- would be useful in guiding patient management. As rheumatologists we need to be aware that depression may occur more commonly in patients with severe rheumatoid arthritis than we had realized."


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lis Cordingley, Rita Prajapati, Darren Plant, Deborah Maskell, Catharine Morgan, Faisal R. Ali, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Anne Barton. Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care & Research, 2013; DOI: 10.1002/acr.22249

Cite This Page:

University of Manchester. "Depression higher than previously reported in people with severe rheumatoid arthritis." ScienceDaily. ScienceDaily, 21 January 2014. <www.sciencedaily.com/releases/2014/01/140121130907.htm>.
University of Manchester. (2014, January 21). Depression higher than previously reported in people with severe rheumatoid arthritis. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/01/140121130907.htm
University of Manchester. "Depression higher than previously reported in people with severe rheumatoid arthritis." ScienceDaily. www.sciencedaily.com/releases/2014/01/140121130907.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins