Featured Research

from universities, journals, and other organizations

Depression higher than previously reported in people with severe rheumatoid arthritis

Date:
January 21, 2014
Source:
University of Manchester
Summary:
Levels of depression and anxiety in people with severe rheumatoid arthritis are higher than previously reported, according to new research. As a result of their findings, a multi-center team says that patients with severe active disease, who are waiting to go onto a biological therapy, should be routinely screened for depression by their doctors.

As a result of their findings, a multi-center team led by researchers at the Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester, say that patients with severe active disease, who are waiting to go onto a biological therapy, should be routinely screened for depression by their doctors.

Related Articles


The team, led by Professor Anne Barton, part of the National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit theme lead, also suggest that the way that disease activity in rheumatoid arthritis is currently recorded should be changed in order to improve the way that patients are managed. Their findings are published in the journal Arthritis Care and Research.

Rheumatoid arthritis is a serious, inflammatory, auto-immune condition that affects the joints and the body's internal organs leading to chronic pain and fatigue. New biological therapies have transformed the treatment of people with severe disease in the past decade, although some patients do not adequately respond to these drugs.

The team carried out an observational study of 322 patients with severe rheumatoid arthritis who were waiting to go on biologic therapy.

The aim of the study was to investigate the impact of psychological factors upon each of the different parts of the current measure of disease called the DAS28. The DAS28 score takes into account the number of tender and swollen joints and the level of inflammation in the body. It also includes a subjective, patient-reported measure based on how well the patient is feeling.

The team found that subjective measures of response were more likely to be influenced by psychological factors such as mood or beliefs about their illness and the therapies used.

"This may seem obvious but has not been reported before and is important because without treating the depression, the patient's DAS28 score might not improve as much as it should on a biological drug, and doctors may assume the drug is ineffective," explained Dr Lis Cordingley, a health psychologist who was the lead author on the paper.

Professor Barton added: "This is the first study of its kind in patients with high levels of active disease, and suggests that routinely assessing a patient's moods and beliefs -- separate to their physical state -- would be useful in guiding patient management. As rheumatologists we need to be aware that depression may occur more commonly in patients with severe rheumatoid arthritis than we had realized."


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lis Cordingley, Rita Prajapati, Darren Plant, Deborah Maskell, Catharine Morgan, Faisal R. Ali, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Anne Barton. Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care & Research, 2013; DOI: 10.1002/acr.22249

Cite This Page:

University of Manchester. "Depression higher than previously reported in people with severe rheumatoid arthritis." ScienceDaily. ScienceDaily, 21 January 2014. <www.sciencedaily.com/releases/2014/01/140121130907.htm>.
University of Manchester. (2014, January 21). Depression higher than previously reported in people with severe rheumatoid arthritis. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/01/140121130907.htm
University of Manchester. "Depression higher than previously reported in people with severe rheumatoid arthritis." ScienceDaily. www.sciencedaily.com/releases/2014/01/140121130907.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins