Featured Research

from universities, journals, and other organizations

Large amounts of folic acid shown to promote growth of breast cancer in rats

Date:
January 21, 2014
Source:
St. Michael's Hospital
Summary:
Folic acid supplements at levels consumed by breast cancer patients and survivors in North America promoted the growth of existing breast cancer in rats, new research found.

Folic acid supplements at levels consumed by breast cancer patients and survivors in North America promoted the growth of existing breast cancer in rats, new research found.

The role of folate, a B vitamin, and its synthetic form, folic acid, in the development and progression of breast cancer is highly controversial. Although some studies have found it may offer protection against breast cancer, recent studies have suggested that taking high amounts of folic acid may increase the risk of developing breast cancer.

Dr. Young-In Kim, a physician and researcher at St. Michael's Hospital, said his lab has shown for the first time that folic acid supplements in doses 2.5 to five times the daily requirement "significantly promotes" the growth of existing pre-cancerous or cancerous cells in the mammary glands of rats. His research was published today in the online journal PLOS ONE.

"This is a critically important issue because breast cancer patients and survivors in North America are exposed to high levels of folic acid through folic acid fortification in food and widespread use of vitamin supplements after a cancer diagnosis," Dr. Kim said. "Cancer patients and survivors in North America have a high prevalence of multivitamin and supplement use, with breast cancer patients and survivors having the highest prevalence."

The amount of folic acid consumed in North America has increased dramatically in the past 15 years. Women are routinely advised to take folic acid supplements before becoming pregnant and while pregnant to prevent neural tube birth defects such as spina bifida. Since 1998, the Canadian and U.S. governments have required food manufacturers to add folic acid to white flour, enriched pasta and cornmeal products as a way of ensuring women receive enough of the B vitamin. In addition, up to 30 to 40 per cent of North Americans take folic acid supplements for possible but as yet unproven health benefits.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. The original article was written by Leslie Shepherd. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shaidah Deghan Manshadi, Lisa Ishiguro, Kyoung-Jin Sohn, Alan Medline, Richard Renlund, Ruth Croxford, Young-In Kim. Folic Acid Supplementation Promotes Mammary Tumor Progression in a Rat Model. PLoS ONE, 2014; 9 (1): e84635 DOI: 10.1371/journal.pone.0084635

Cite This Page:

St. Michael's Hospital. "Large amounts of folic acid shown to promote growth of breast cancer in rats." ScienceDaily. ScienceDaily, 21 January 2014. <www.sciencedaily.com/releases/2014/01/140121183414.htm>.
St. Michael's Hospital. (2014, January 21). Large amounts of folic acid shown to promote growth of breast cancer in rats. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140121183414.htm
St. Michael's Hospital. "Large amounts of folic acid shown to promote growth of breast cancer in rats." ScienceDaily. www.sciencedaily.com/releases/2014/01/140121183414.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins