Featured Research

from universities, journals, and other organizations

Large amounts of folic acid shown to promote growth of breast cancer in rats

Date:
January 21, 2014
Source:
St. Michael's Hospital
Summary:
Folic acid supplements at levels consumed by breast cancer patients and survivors in North America promoted the growth of existing breast cancer in rats, new research found.

Folic acid supplements at levels consumed by breast cancer patients and survivors in North America promoted the growth of existing breast cancer in rats, new research found.

The role of folate, a B vitamin, and its synthetic form, folic acid, in the development and progression of breast cancer is highly controversial. Although some studies have found it may offer protection against breast cancer, recent studies have suggested that taking high amounts of folic acid may increase the risk of developing breast cancer.

Dr. Young-In Kim, a physician and researcher at St. Michael's Hospital, said his lab has shown for the first time that folic acid supplements in doses 2.5 to five times the daily requirement "significantly promotes" the growth of existing pre-cancerous or cancerous cells in the mammary glands of rats. His research was published today in the online journal PLOS ONE.

"This is a critically important issue because breast cancer patients and survivors in North America are exposed to high levels of folic acid through folic acid fortification in food and widespread use of vitamin supplements after a cancer diagnosis," Dr. Kim said. "Cancer patients and survivors in North America have a high prevalence of multivitamin and supplement use, with breast cancer patients and survivors having the highest prevalence."

The amount of folic acid consumed in North America has increased dramatically in the past 15 years. Women are routinely advised to take folic acid supplements before becoming pregnant and while pregnant to prevent neural tube birth defects such as spina bifida. Since 1998, the Canadian and U.S. governments have required food manufacturers to add folic acid to white flour, enriched pasta and cornmeal products as a way of ensuring women receive enough of the B vitamin. In addition, up to 30 to 40 per cent of North Americans take folic acid supplements for possible but as yet unproven health benefits.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. The original article was written by Leslie Shepherd. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shaidah Deghan Manshadi, Lisa Ishiguro, Kyoung-Jin Sohn, Alan Medline, Richard Renlund, Ruth Croxford, Young-In Kim. Folic Acid Supplementation Promotes Mammary Tumor Progression in a Rat Model. PLoS ONE, 2014; 9 (1): e84635 DOI: 10.1371/journal.pone.0084635

Cite This Page:

St. Michael's Hospital. "Large amounts of folic acid shown to promote growth of breast cancer in rats." ScienceDaily. ScienceDaily, 21 January 2014. <www.sciencedaily.com/releases/2014/01/140121183414.htm>.
St. Michael's Hospital. (2014, January 21). Large amounts of folic acid shown to promote growth of breast cancer in rats. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2014/01/140121183414.htm
St. Michael's Hospital. "Large amounts of folic acid shown to promote growth of breast cancer in rats." ScienceDaily. www.sciencedaily.com/releases/2014/01/140121183414.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins