Featured Research

from universities, journals, and other organizations

Holographic diagnostics in medicine

Date:
January 22, 2014
Source:
University of Cambridge
Summary:
'Smart' holograms, which are currently being tested to monitor diabetes, and could be used to monitor a wide range of medical and environmental conditions in future, have been developed by researchers.

Responsive holograms that change color in the presence of certain compounds are being developed into portable medical tests and devices, which could be used to monitor conditions such as diabetes, cardiac function, infections, electrolyte or hormone imbalance easily and inexpensively.

The 'smart' holograms can be used to test blood, breath, urine, saliva or tear fluid for a wide range of compounds, such as glucose, alcohol, hormones, drugs, or bacteria. When one of these compounds is present, the hologram changes color, potentially making the monitoring of various conditions as simple as checking the color of the hologram against a color gradient. Clinical trials of the holographic sensors to monitor glucose levels and urinary tract infections in diabetic patients are currently underway at Addenbrooke's Hospital, part of Cambridge University Hospitals.

The interdisciplinary project by researchers from the University of Cambridge uses a highly absorbent material known as a hydrogel, similar to contact lenses, impregnated with tiny particles of silver. Using a single laser pulse, the silver nanoparticles are formed into three-dimensional holograms of predetermined shapes in a fraction of a second.

When in the presence of certain compounds, the hydrogels either shrink or swell, causing the color of the hologram to change to any other color in the entire visible spectrum, the first time that this has been achieved in any hydrogel-based sensor.

A major advantage of the technology is that the holograms can be constructed in a fraction of a second, making the technology highly suitable for mass production. Details of the holographic sensors were recently published in the journal Advanced Optical Materials.

"Currently, a lot of medical testing is performed on large, expensive equipment," said Ali Yetisen, a PhD student in the Department of Chemical Engineering & Biotechnology, who led the research. "While these sorts of inexpensive, portable tests aren't meant to replace a doctor, holograms could enable people to easily monitor their own health, and could be useful for early diagnosis, which is critical for so many conditions."

The holographic sensors produced by the Cambridge team are much faster, easier and cheaper to produce than current technologies -- it is estimated that a single sensor would cost just ten pence to make, which would make it particularly useful in the developing world, where the costs of current glucose tests can be prohibitive. The entire sensing process is reversible, and the same sensor may be reused many times, after which it may be easily disposed of.

In addition to the clinical tests currently underway at Addenbrooke's against current state-of-the-art glucose monitoring technology, the researchers are developing a prototype smartphone-based test suitable for both clinical and home testing of diabetes and clinically relevant conditions.

"In addition to medical applications, the holographic technology also has potential uses in security applications, such as the detection of counterfeit medicine, which is thought to cause hundreds of thousands of deaths each year," said Dr Fernando da Cruz Vasconcellos, Post-Doctoral Researcher in Professor Chris Lowe's group and a co-author of this study.


Story Source:

The above story is based on materials provided by University of Cambridge. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ali K. Yetisen, Haider Butt, Fernando da Cruz Vasconcellos, Yunuen Montelongo, Colin A. B. Davidson, Jeff Blyth, Leon Chan, J. Bryan Carmody, Silvia Vignolini, Ullrich Steiner, Jeremy J. Baumberg, Timothy D. Wilkinson, Christopher R. Lowe. Light-Directed Writing of Chemically Tunable Narrow-Band Holographic Sensors. Advanced Optical Materials, 2013; DOI: 10.1002/adom.201300375

Cite This Page:

University of Cambridge. "Holographic diagnostics in medicine." ScienceDaily. ScienceDaily, 22 January 2014. <www.sciencedaily.com/releases/2014/01/140122134146.htm>.
University of Cambridge. (2014, January 22). Holographic diagnostics in medicine. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140122134146.htm
University of Cambridge. "Holographic diagnostics in medicine." ScienceDaily. www.sciencedaily.com/releases/2014/01/140122134146.htm (accessed July 31, 2014).

Share This




More Matter & Energy News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Britain Testing Driverless Cars on Roadways

Britain Testing Driverless Cars on Roadways

AP (July 30, 2014) — British officials said on Wednesday that driverless cars will be tested on roads in as many as three cities in a trial program set to begin in January. Officials said the tests will last up to three years. (July 30) Video provided by AP
Powered by NewsLook.com
Amid Drought, UCLA Sees Only Water

Amid Drought, UCLA Sees Only Water

AP (July 30, 2014) — A ruptured 93-year-old water main left the UCLA campus awash in 8 million gallons of water in the middle of California's worst drought in decades. (July 30) Video provided by AP
Powered by NewsLook.com
Smartphone Powered Paper Plane Debuts at Airshow

Smartphone Powered Paper Plane Debuts at Airshow

AP (July 30, 2014) — Smartphone powered paper airplane that was popular on crowdfunding website KickStarter makes its debut at Wisconsin airshow (July 30) Video provided by AP
Powered by NewsLook.com
U.K. To Allow Driverless Cars On Public Roads

U.K. To Allow Driverless Cars On Public Roads

Newsy (July 30, 2014) — Driverless cars could soon become a staple on U.K. city streets, as they're set to be introduced to a few cities in 2015. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins