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New subgroup of schizophrenia patients with motor disorders

Date:
January 29, 2014
Source:
IDIBELL-Bellvitge Biomedical Research Institute
Summary:
Researchers have identified a new subgroup of patients suffering from schizophrenia characterized by motor disorders.

Researchers led by Marta Barrachina, Institute of Neuropathology of the Bellvitge Biomedical Research Institute (IDIBELL) have identified a new subgroup of patients suffering from schizophrenia characterized by motor disorders.

The study, which was conducted in collaboration with the research team Mairena Martin at the University of Castilla La Mancha at Ciudad Real and clinical researchers of the Health Park Sant Joan de Deu at Sant Boi de Llobregat, has been published in the online edition of the Journal of Psychiatric Research and was funded by the TV3 Marathon in its 2008 edition.

Schizophrenia is a serious mental illness. From a clinical point of view is considered grouping several diseases that are not well defined or characterized by biomarkers.

Barrachina team studies the A2A adenosine receptor, which is highly expressed in the basal ganglia at the central nervous system and is involved in the control of movement. Furthermore this protein inhibits the activity of dopamine D2 receptor, hyperactivated in schizophrenia patients and typical antipsychotics target.

"We studied the post- mortem brains of patients," explains Barrachina "and we found that 50% had very low levels of adenosine A2A receptor. Interestingly, when comparing these data with clinical information provided by the clinical investigators of the study, we note that these patients had motor disorders." "In addition, we identified an epigenetic mechanism associated with the decreased receptor expression."

According to the researcher, this finding allows to "identify a new subset of schizophrenia patients with motor disorders."

Proposal for combined therapy

This study opens the door to a clinical trial, based on radioimage, which would detect the levels of this protein and identify these patients and also to confirm the results obtained in the postmortem brains of patients. Barrachina team proposes to apply a specific combination therapy of antipsychotics and agonists of A2A adenosine. "Thus, the activity of adenosine A2A receptor will be favoured, reducing the dose of antipsychotics."


Story Source:

The above story is based on materials provided by IDIBELL-Bellvitge Biomedical Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Villar-Menéndez I, Díaz-Sánchez S, Blanch M, Albasanz JL, Pereira-Veiga T, Monje A, Planchat LM, Ferrer I, Martín M and Barrachina M. Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia. Journal Psyquiatric Research, January 2014

Cite This Page:

IDIBELL-Bellvitge Biomedical Research Institute. "New subgroup of schizophrenia patients with motor disorders." ScienceDaily. ScienceDaily, 29 January 2014. <www.sciencedaily.com/releases/2014/01/140129114936.htm>.
IDIBELL-Bellvitge Biomedical Research Institute. (2014, January 29). New subgroup of schizophrenia patients with motor disorders. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140129114936.htm
IDIBELL-Bellvitge Biomedical Research Institute. "New subgroup of schizophrenia patients with motor disorders." ScienceDaily. www.sciencedaily.com/releases/2014/01/140129114936.htm (accessed July 31, 2014).

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