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Finding could explain age-related decline in motor function

Date:
February 7, 2014
Source:
University of Texas Health Science Center at San Antonio
Summary:
A team of researchers has found a clue as to why muscles weaken with age. The team observed a change in homeostatic set points in neuromuscular junction synapses of aged fruit flies.

Scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio have found a clue as to why muscles weaken with age. In a study published today in The Journal of Neuroscience, they report the first evidence that "set points" in the nervous system are not inalterably determined during development but instead can be reset with age. They observed a change in set point that resulted in significantly diminished motor function in aging fruit flies.

"The body has a set point for temperature (98.6 degrees), a set point for salt level in the blood, and other homeostatic (steady-state) set points that are important for maintaining stable functions throughout life," said study senior author Ben Eaton, Ph.D., assistant professor of physiology at the Health Science Center. "Evidence also points to the existence of set points in the nervous system, but it has never been observed that they change, until now."

Dr. Eaton and lead author Rebekah Mahoney, a graduate student, recorded changes in the neuromuscular junction synapses of aging fruit flies. These synapses are spaces where neurons exchange electrical signals to enable motor functions such as walking and smiling. "We observed a change in the synapse, indicating that the homeostatic mechanism had adjusted to maintain a new set point in the older animal," Mahoney said.

The change was nearly 200 percent, and the researchers predicted that it would leave muscles more vulnerable to exhaustion.

Aside from impairing movement in aging animals, a new functional set point in neuromuscular junctions could put the synapse at risk for developing neurodegeneration -- the hallmark of disorders such as Alzheimer's and Parkinson's diseases, Mahoney said.

"Observing a change in the set point in synapses alters our paradigms about how we think age affects the function of the nervous system," she said.

It appears that a similar change could lead to effects on learning and memory in old age. An understanding of this phenomenon would be invaluable and could lead to development of novel therapies for those issues, as well.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. E. Mahoney, J. M. Rawson, B. A. Eaton. An Age-Dependent Change in the Set Point of Synaptic Homeostasis. Journal of Neuroscience, 2014; 34 (6): 2111 DOI: 10.1523/JNEUROSCI.3556-13.2014

Cite This Page:

University of Texas Health Science Center at San Antonio. "Finding could explain age-related decline in motor function." ScienceDaily. ScienceDaily, 7 February 2014. <www.sciencedaily.com/releases/2014/02/140207094054.htm>.
University of Texas Health Science Center at San Antonio. (2014, February 7). Finding could explain age-related decline in motor function. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2014/02/140207094054.htm
University of Texas Health Science Center at San Antonio. "Finding could explain age-related decline in motor function." ScienceDaily. www.sciencedaily.com/releases/2014/02/140207094054.htm (accessed April 20, 2014).

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