Featured Research

from universities, journals, and other organizations

Elevated brain aluminium, early onset Alzheimer's disease in an individual occupationally exposed to aluminium

Date:
February 12, 2014
Source:
Keele University
Summary:
Research has shown for the first time that an individual who was exposed to aluminum at work and died of Alzheimer’s disease had high levels of aluminum in the brain. While aluminum is a known neurotoxin and occupational exposure to aluminum has been implicated in neurological disease, including Alzheimer’s disease, this finding is believed to be the first record of a direct link between Alzheimer’s disease and elevated brain aluminum following occupational exposure to the metal.

Computed tomography of human brain (stock image). The man in this study began to work with the preparation of a novel material used as insulation in the nuclear fuel and space industries. This work exposed him to aluminium sulphate 'dust' on a daily basis over 8 years.
Credit: beccarra / Fotolia

Research at Keele University in Staffordshire, UK, has shown for the first time that an individual who was exposed to aluminum at work and died of Alzheimer's disease had high levels of aluminum in the brain.

While aluminum is a known neurotoxin and occupational exposure to aluminum has been implicated in neurological disease, including Alzheimer's disease, this finding is believed to be the first record of a direct link between Alzheimer's disease and elevated brain aluminum following occupational exposure to the metal.

In 2003 a 58-year-old Caucasian male with no previous medical history of note was diagnosed with Alzheimer's disease. Ten years previous to this the man, from the north-east of England, began to work with the preparation of a novel material (DARMATT KM1) used as insulation in the nuclear fuel and space industries. This work exposed him to aluminum sulphate 'dust' on a daily basis over 8 years. An 'ordinary' dust mask was supplied to protect against inhalation of the materials. Within a short time of starting this work the man complained of headaches, tiredness and mouth ulcers. By 1999 he started to show problems in relation to memory and suffered depression.

Following his death, aged 66, in 2011, a neuropathological examination confirmed advance stage Alzheimer's disease. There then followed the most comprehensive investigation ever of the aluminum content of the frontal lobe of a single individual with 49 different tissue samples being measured for aluminum.

Professor Chris Exley, of The Birchall Centre, at Keele University, said: "The results showed unequivocally that the frontal lobe contained an average aluminum content which was at least four times higher than might be expected for an age-matched control brain.

"The observation that air-borne aluminum dust was most likely responsible for the elevated levels of aluminum in the brain must then heavily implicate the nose and possibly the lungs as the main routes of entry of aluminum into the body and the brain.

"Overall, these results suggest very strongly that occupational exposure to aluminum contributed significantly to the untimely death of this individual with Alzheimer's disease."


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Cite This Page:

Keele University. "Elevated brain aluminium, early onset Alzheimer's disease in an individual occupationally exposed to aluminium." ScienceDaily. ScienceDaily, 12 February 2014. <www.sciencedaily.com/releases/2014/02/140212093300.htm>.
Keele University. (2014, February 12). Elevated brain aluminium, early onset Alzheimer's disease in an individual occupationally exposed to aluminium. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/02/140212093300.htm
Keele University. "Elevated brain aluminium, early onset Alzheimer's disease in an individual occupationally exposed to aluminium." ScienceDaily. www.sciencedaily.com/releases/2014/02/140212093300.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins