Featured Research

from universities, journals, and other organizations

New treatment for metastatic prostate cancer

Date:
February 12, 2014
Source:
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center
Summary:
An American hospital has treated three men with a recently FDA-approved treatment for prostate cancer, which offers new options for men whose cancer has spread to their bones. The treatment’s trade name is Xofigo (or radium-223 dichloride). It is an alpha particle-emitting radioactive therapeutic agent with an anti-tumor effect.

Dartmouth-Hitchcock Norris Cotton Cancer Center has treated three men with a recently FDA-approved treatment, which offers new options for men whose prostate cancer has spread to their bones. The treatment's trade name is Xofigoฎ (or radium-223 dichloride). It is an alpha particle-emitting radioactive therapeutic agent with an anti-tumor effect.

Treatment entails an injection each week, up to six injections if needed. "When compared with the best existing standard of care, research shows that patients receiving radium-223 injections live longer," said Thomas C. Sroka, MD, PhD, radiation oncologist, Norris Cotton Cancer Center. "It is also very tolerable," he said, "with few side effects."

Sroka explains that the agent is made to look like calcium so it is easily absorbed into the bone. "This radioisotope is precise, settling into the right place, with minimal damage to surrounding tissue," said Sroka. It targets area of increased bone turnover, which is the case in bone metastases. The high-energy alpha-particle from Radium-223 deposits its energy over a very short distance (less than 100 micrometers), which is how it limits damage to surrounding normal tissue.

Xofigo was approved by FDA in May of 2013 and is the first agent of its kind. Clinical trials of the drug showed an improvement of overall survival time from 11.3 months to 14.9 months versus placebo. The most common side effects are nausea, diarrhea, vomiting, and peripheral edema.

Prostate cancer is the most common cancer among men in the United States. If it spreads to other places in the body, prostate cancer predominantly settles in the bones. Bone metastases are a leading cause of death in men with prostate cancer.


Story Source:

The above story is based on materials provided by Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "New treatment for metastatic prostate cancer." ScienceDaily. ScienceDaily, 12 February 2014. <www.sciencedaily.com/releases/2014/02/140212144513.htm>.
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. (2014, February 12). New treatment for metastatic prostate cancer. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2014/02/140212144513.htm
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "New treatment for metastatic prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140212144513.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins