Featured Research

from universities, journals, and other organizations

Cortisol: Stress hormone linked to frailty

Date:
February 20, 2014
Source:
Endocrine Society
Summary:
Lower morning and higher evening cortisol levels contribute to frailty in older individuals, according to new research. Frailty confers a high risk for institutionalization and increased risk of mortality and is characterized by unintentional weight loss, feelings of exhaustion and fatigue, physical inactivity, slow gait speed and low grip strength. Neuroendocrine function, including cortisol secretion, is thought to be involved in the etiology of frailty, but until now the underlying biological mechanisms have not been well understood.

Frailty confers a high risk for institutionalization and increased risk of mortality and is characterized by unintentional weight loss, feelings of exhaustion and fatigue, physical inactivity, slow gait speed and low grip strength.
Credit: © milphoto / Fotolia

Lower morning and higher evening cortisol levels contribute to frailty in older individuals, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Frailty confers a high risk for institutionalization and increased risk of mortality and is characterized by unintentional weight loss, feelings of exhaustion and fatigue, physical inactivity, slow gait speed and low grip strength. Neuroendocrine function, including cortisol secretion, is thought to be involved in the etiology of frailty, but until now the underlying biological mechanisms have not been well understood.

"Cortisol typically follows a distinct daily pattern with the highest level in the morning and the lowest basal level at night," said Karl-Heinz Ladwig, PhD, MD, of Helmholtz Zentrum Mόnchen in Neuherberg, Germany and an author of the study. "Our findings showed dysregulated cortisol secretion, as featured by a smaller morning to evening cortisol level ratio, was significantly associated with frailty status."

In this study, researchers conducted a cross-sectional analysis of 745 participants between the ages of 65 and 90 years. Cortisol levels were measured using saliva samples at three points: awakening, 30 minutes after awakening and evening. Participants were classified as frail if three or more of the following criteria were met: exhaustion, physical inactivity, low walking speed, weakness (measured by grip strength) or weight loss (loss of more than 5 kilograms in the past six months).

"Our results suggest a link between disrupted cortisol regulation and loss of muscle mass and strength, as the underlying pathophysiology of frailty," said Hamimatunnisa Johar, a PhD student at Helmholtz Zentrum Mόnchen and an author of the study. "In a clinical setting assessment of frailty can be time-consuming, and our findings show measurements of cortisol may offer a feasible alternative."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Cortisol: Stress hormone linked to frailty." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220131349.htm>.
Endocrine Society. (2014, February 20). Cortisol: Stress hormone linked to frailty. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/02/140220131349.htm
Endocrine Society. "Cortisol: Stress hormone linked to frailty." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220131349.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) — Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) — Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins