Featured Research

from universities, journals, and other organizations

Neuroscientists forge path toward understanding human brain

Date:
March 13, 2014
Source:
Florida Atlantic University
Summary:
Metastable dynamics -- a subtle blend of integration and segregation in the brain that occurs on multiple levels (cells, brain regions, networks) -- underlies the real-time coordination necessary for the brain’s dynamic cognitive, behavioral and social functions, neuroscientists have found.

Florida Atlantic University neuroscientist Emmanuelle Tognoli, Ph.D., and J.A. Scott Kelso, Ph.D., neuroscientist and eminent scholar in science, at the Center for Complex Systems and Brain Sciences at FAU, recently published research in the journal Neuron titled "The Metastable Brain." The article indicates that metastable dynamics -- a subtle blend of integration and segregation in the brain that occurs on multiple levels (cells, brain regions, networks) -- underlies the real-time coordination necessary for the brain's dynamic cognitive, behavioral and social functions.

"Metastability can be visualized in terms of a line; with too much segregation on the left end of the line and too much integration on the right end of the line leading to disorders. The brain functions best somewhere in the middle where there is a dynamic balance of segregation and integration," said Tognoli. "If it is out of balance, it can lead to diseases such as autism, schizophrenia and epilepsy."

This research is timely as federal funding in support of the B.R.A.I.N. Initiative was approved early this year. The initiative is intended to accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought.

"We know how neurons fire and we know they are connected," said Francis Collins, director of the U.S. National Institutes of Health in a 2013 interview with the Wall Street Journal. "We don't know how they act in concert to govern behavior, the essential question in treating neurological disease and mental health disorders."

While the majority of research conducted nationally is focused on "mapping" the brain, Tognoli and Kelso's work focuses on how brain activity evolves in space and time on a millisecond timescale during the course of ordinary behavior. The researchers use a quantitative approach to brain coordination to learn about the whole "parameter space," or all the space on the line between segregation and integration.

One of the next steps in this line of research will be to analyze which drugs are sound based on the theory of metastability. Furthermore, researchers can study which interventions will produce ineffective or counterintuitive consequences -- as would happen with drugs that enhance segregation.

Kelso, Tognoli and their colleagues' work on the human brain and behavior is carried out on FAU's Boca Raton campus under the auspices of the National Institute of Mental Health. FAU also has a research cluster of close to three dozen neuroscientists working at the John D. MacArthur Campus in Jupiter. These neuroscientists work on complementary ways to understand the brain using animal models and focusing on neural circuitry in collaboration with researchers from Scripps Florida and Max Planck Florida Institute.


Story Source:

The above story is based on materials provided by Florida Atlantic University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Emmanuelle Tognoli, J.A.Scott Kelso. The Metastable Brain. Neuron, 2014; 81 (1): 35 DOI: 10.1016/j.neuron.2013.12.022

Cite This Page:

Florida Atlantic University. "Neuroscientists forge path toward understanding human brain." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313122705.htm>.
Florida Atlantic University. (2014, March 13). Neuroscientists forge path toward understanding human brain. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/03/140313122705.htm
Florida Atlantic University. "Neuroscientists forge path toward understanding human brain." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313122705.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins