Featured Research

from universities, journals, and other organizations

Robust research efforts needed to address challenge of antimicrobial resistance

Date:
March 20, 2014
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Given the evolutionary ability of microbes to rapidly adapt, the threat of antimicrobial resistance likely will never be eliminated. Today, many factors compound the problem, including the inappropriate use of antibiotics and a dwindling supply of new medicines, leading to a global crisis of antimicrobial resistance.

This is an electron micrograph of a human neutrophil ingesting methicillin-resistant Staphylococcus aureus (purple), a key form of antimicrobial resistance research NIAID is pursuing.
Credit: NIAID

Given the evolutionary ability of microbes to rapidly adapt, the threat of antimicrobial resistance likely will never be eliminated. Today, many factors compound the problem, including the inappropriate use of antibiotics and a dwindling supply of new medicines, leading to a global crisis of antimicrobial resistance. This crisis must be addressed with a multi-faceted approach that includes a strong base of basic, clinical and translational research, according to a new commentary in the journal JAMA from Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and colleague Hilary D. Marston, M.D., M.P.H.

In the United States alone, drug-resistant bacterial infections cause an estimated 23,000 deaths each year. These infections also are a hefty economic burden to the U.S. health care system: $20 billion annually in direct costs with an additional estimated $35 billion in lost productivity, according to the Centers for Disease Control and Prevention.

As discussed in a new report NIAID's Antimicrobial Resistance Program: Current Status and Future Directions, 2014, NIAID recently refocused its antimicrobial resistance research efforts to address key scientific challenges. Among the innovative complementary approaches NIAID is pursuing: examining the comprehensive biology and genetic makeup of specific microbes to understand how bacteria become resistant and to identify new targets for point-of-care diagnostics, drugs and vaccines; and developing vaccines to prevent infection with such drug-resistant microbes as Staphylococcus aureus and Neisseria gonorrhoeae. Additionally, NIAID is working to harness healthy bacteria in the human body to combat future infection; target the mechanisms by which bacteria cause disease; and design new antibiotics that are less likely to generate resistance, while also repurposing existing treatments and using natural predators, such as bacteriophages -- viruses that infect and destroy specific bacteria. To further clinical research, NIAID also recently established a Leadership Group to design, implement, and manage the clinical research agenda for a new antibacterial resistance research network.

Such research efforts, combined with improved surveillance, prevention efforts, diagnostics and industry incentives to drive development of new antimicrobial medicines are essential to meeting the continual threat of antimicrobial resistance, the authors write.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anthony S. Fauci, Hilary D. Marston. The Perpetual Challenge of Antimicrobial Resistance. JAMA, 2014; DOI: 10.1001/jama.2014.2465

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Robust research efforts needed to address challenge of antimicrobial resistance." ScienceDaily. ScienceDaily, 20 March 2014. <www.sciencedaily.com/releases/2014/03/140320111859.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2014, March 20). Robust research efforts needed to address challenge of antimicrobial resistance. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/03/140320111859.htm
NIH/National Institute of Allergy and Infectious Diseases. "Robust research efforts needed to address challenge of antimicrobial resistance." ScienceDaily. www.sciencedaily.com/releases/2014/03/140320111859.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) — A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com
Common Antibiotic Could Lead To Heart-Related Death

Common Antibiotic Could Lead To Heart-Related Death

Newsy (Aug. 20, 2014) — Danish researchers discovered patients taking clarithromycin have an increased risk of dying from a heart-related issue. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins