Featured Research

from universities, journals, and other organizations

Certain genetic variants may put bladder cancer patients at increased risk of recurrence

Date:
March 26, 2014
Source:
Wiley
Summary:
In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women, with many patients experiencing recurrence after treatment. A new study indicates that inheriting certain DNA sequences can affect a patient's prognosis. The findings may help physicians identify sub-groups of bladder cancer patients who should receive intensive treatment and monitoring.

In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women, with many patients experiencing recurrence after treatment. A new study published in BJU International indicates that inheriting certain DNA sequences can affect a patient's prognosis. The findings may help physicians identify sub-groups of bladder cancer patients who should receive intensive treatment and monitoring.

Nearly half of patients diagnosed with bladder cancer experience tumor recurrences, but it is difficult to predict which patients are at risk. Angeline Andrew, PhD, of the Dartmouth-Hitchcock Norris Cotton Cancer Center in Lebanon, New Hampshire and her colleagues analyzed the genes of 563 patients to identify genetic variants that modify time to bladder cancer recurrence and patient survival. The investigators isolated DNA from immune cells circulating in the blood, and they examined genes involved in major biological processes linked to cancer: cell death, proliferation, DNA repair, hormone regulation, immune surveillance, and cellular metabolism. After diagnosis, patients were followed over time to ascertain recurrence and survival status. Patients were followed for a median of 5.4 years, and half of patients experienced at least one recurrence.

The team found that patients with variants in the aldehyde dehydrogenase 2 (ALDH2) gene were likely to experience bladder cancer recurrence shortly after treatment. This gene encodes an enzyme involved in alcohol metabolism. Time to recurrence was also shorter for patients who had a variant in the vascular cellular adhesion molecule 1 (VCAM1) gene and were treated with immunotherapy. VCAM1 encodes a glycoprotein involved in the development of lymphoid tissues. Patients who had non-invasive tumors and a variant in the DNA repair gene XRCC4 tended to live longer than patients who did not have the variant.

The researchers noted that the novel associations between genetic variants and bladder cancer recurrence uncovered in this study merit future investigation. "The genetic markers that we found could potentially be useful for individually tailoring surveillance and treatment of bladder cancer patients," said Dr. Andrew.


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Angeline S. Andrew, Jiang Gui, Ting Hu, Asaf Wyszynski, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Sam A. Tanyos, Eben M. Pendleton, Rebecca M. Ekstrom, Zhongze Li, Michael S. Zens, Mark Borsuk, Jason H. Moore and Margaret R. Karagas. Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. BJU International, March 2014 DOI: 10.1111/bju.12641

Cite This Page:

Wiley. "Certain genetic variants may put bladder cancer patients at increased risk of recurrence." ScienceDaily. ScienceDaily, 26 March 2014. <www.sciencedaily.com/releases/2014/03/140326092558.htm>.
Wiley. (2014, March 26). Certain genetic variants may put bladder cancer patients at increased risk of recurrence. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/03/140326092558.htm
Wiley. "Certain genetic variants may put bladder cancer patients at increased risk of recurrence." ScienceDaily. www.sciencedaily.com/releases/2014/03/140326092558.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins