Featured Research

from universities, journals, and other organizations

Potential marker to better identify, resect glioblastoma multiforme tumors

Date:
April 7, 2014
Source:
American Association of Neurological Surgeons (AANS)
Summary:
Researchers have highlighted the results of research that explores whether 5 aminolevulinic-acid fluorescence (5-ALA) offers additional detection benefits compared to intraoperative MRI (iMRI) when dealing with invasive tumors.

Glioblastoma multiforme (GBM) has a history of invasive growth, often extending into neural tissue well beyond MRI contrast-enhancement margins. During a presentation during the 82nd Annual Scientific Meeting of the American Association of Neurological Surgeons (AANS), Jan Coburger, MD, highlighted the results of research that explores whether 5 aminolevulinic-acid fluorescence (5-ALA) offers additional detection benefits compared to intraoperative MRI (iMRI) when dealing with invasive tumors.

Related Articles


For the study 5-Aminoleyulinic acid fluorescence exceeds Gd-DTPA enhanced intraoperative MRI in tumor detection at the border of glioblastoma multiforme: A prospective study based on histopathological assessment, researchers enrolled 34 patients harboring a GBM with intended gross total resection. All patients had surgery using iMRI and 5-ALA guided resection following a specific protocol. A white-light tumor resection was performed first, then spatial location of residual fluorescence was subsequently marked. After that, an iMRI was performed and residual uptake of contrast was marked and navigated biopsies were taken from these areas and from additional areas. Correlations of histopathological findings with imaging results were tested using Spearman's rho.

The researchers found that imaging results of 5-ALA and iMRI were significantly different at the border zone of GBMs, and that 5-ALA has a higher sensitivity and a lower specificity for tumor detection than Gd-DTPAenhanced iMRI. They concluded that for detection of infiltrating tumors, 5-ALA is superior to Gd-DTPA-enhanced iMRI concerning both sensitivity and specificity.


Story Source:

The above story is based on materials provided by American Association of Neurological Surgeons (AANS). Note: Materials may be edited for content and length.


Cite This Page:

American Association of Neurological Surgeons (AANS). "Potential marker to better identify, resect glioblastoma multiforme tumors." ScienceDaily. ScienceDaily, 7 April 2014. <www.sciencedaily.com/releases/2014/04/140407143643.htm>.
American Association of Neurological Surgeons (AANS). (2014, April 7). Potential marker to better identify, resect glioblastoma multiforme tumors. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/04/140407143643.htm
American Association of Neurological Surgeons (AANS). "Potential marker to better identify, resect glioblastoma multiforme tumors." ScienceDaily. www.sciencedaily.com/releases/2014/04/140407143643.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins