Featured Research

from universities, journals, and other organizations

More effective kidney stone treatment, from macroscopic to nanoscale

Date:
April 17, 2014
Source:
International Union of Crystallography
Summary:
Researchers have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible. Kidney stones represent a major medical problem in the western and developing world. If left untreated, apart from being particularly painful, they can lead to renal failure and other complications. In many patients treated successfully, stone recurrence is also a major problem. Clearly a more effective pathological approach to diagnosis and treatment needs to be identified to ensure successful eradication of stones.

This is a SEM image of stones treated by 2 different drugs. Above you see altered crystals with a rough surface, below, you see crystal edges still well defined, suggesting limited effect of treatment.
Credit: Dominique Bazin et al

Researchers in France have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible.

Related Articles


Kidney stones represent a major medical problem in the western and developing world. If left untreated, apart from being particularly painful, they can lead to renal failure and other complications. In many patients treated successfully, stone recurrence is also a major problem. Clearly a more effective pathological approach to diagnosis and treatment needs to be identified to ensure successful eradication of stones.

Worldwide approximately 1:7000 births are affected by cystinuria, the most frequent cause of stone formation among genetic diseases. Whilst stones are treatable many therapies exist with varying results depending on the type of stone and severity of the incidence.

Cystine stones, of which there are two forms, are composed of tiny micrometre-size crystallites, which are made up of a collection of nanocrystals. Both forms of cystine stone behave in a particular way under different chemical conditions induced by the drug or drugs administered.

By crystallographic techniques Dominique Bazin, Director of Research at Universitι Paris-Sud 11, France (now at LCMCP-College de France), and co-workers were able to understand how some of the methods employed to medically treat the stones have different effects on the stone, from reducing the size of both nanocrystals and crystallites to changing the shape and space occupied by the crystallites at the macroscale.

Clear evidence is now available to help doctors diagnose and prescribe the correct drugs for patients with kidney stones more successfully. Trials did indicate, however, that a lot of the success that can be seen in recovery rates and non-recurrence does depend on the patient also complying with the drug regime prescribed.


Story Source:

The above story is based on materials provided by International Union of Crystallography. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dominique Bazin et al. Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale? J. Appl. Cryst, 47, 719-725 DOI: 10.1107/S1600576714004658]

Cite This Page:

International Union of Crystallography. "More effective kidney stone treatment, from macroscopic to nanoscale." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417101156.htm>.
International Union of Crystallography. (2014, April 17). More effective kidney stone treatment, from macroscopic to nanoscale. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2014/04/140417101156.htm
International Union of Crystallography. "More effective kidney stone treatment, from macroscopic to nanoscale." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417101156.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) — Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) — NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) — A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) — Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins