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More effective kidney stone treatment, from macroscopic to nanoscale

Date:
April 17, 2014
Source:
International Union of Crystallography
Summary:
Researchers have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible. Kidney stones represent a major medical problem in the western and developing world. If left untreated, apart from being particularly painful, they can lead to renal failure and other complications. In many patients treated successfully, stone recurrence is also a major problem. Clearly a more effective pathological approach to diagnosis and treatment needs to be identified to ensure successful eradication of stones.
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This is a SEM image of stones treated by 2 different drugs. Above you see altered crystals with a rough surface, below, you see crystal edges still well defined, suggesting limited effect of treatment.
Credit: Dominique Bazin et al

Researchers in France have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible.

Kidney stones represent a major medical problem in the western and developing world. If left untreated, apart from being particularly painful, they can lead to renal failure and other complications. In many patients treated successfully, stone recurrence is also a major problem. Clearly a more effective pathological approach to diagnosis and treatment needs to be identified to ensure successful eradication of stones.

Worldwide approximately 1:7000 births are affected by cystinuria, the most frequent cause of stone formation among genetic diseases. Whilst stones are treatable many therapies exist with varying results depending on the type of stone and severity of the incidence.

Cystine stones, of which there are two forms, are composed of tiny micrometre-size crystallites, which are made up of a collection of nanocrystals. Both forms of cystine stone behave in a particular way under different chemical conditions induced by the drug or drugs administered.

By crystallographic techniques Dominique Bazin, Director of Research at Université Paris-Sud 11, France (now at LCMCP-College de France), and co-workers were able to understand how some of the methods employed to medically treat the stones have different effects on the stone, from reducing the size of both nanocrystals and crystallites to changing the shape and space occupied by the crystallites at the macroscale.

Clear evidence is now available to help doctors diagnose and prescribe the correct drugs for patients with kidney stones more successfully. Trials did indicate, however, that a lot of the success that can be seen in recovery rates and non-recurrence does depend on the patient also complying with the drug regime prescribed.


Story Source:

The above story is based on materials provided by International Union of Crystallography. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dominique Bazin et al. Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale? J. Appl. Cryst, 47, 719-725 DOI: 10.1107/S1600576714004658]

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International Union of Crystallography. "More effective kidney stone treatment, from macroscopic to nanoscale." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417101156.htm>.
International Union of Crystallography. (2014, April 17). More effective kidney stone treatment, from macroscopic to nanoscale. ScienceDaily. Retrieved May 30, 2015 from www.sciencedaily.com/releases/2014/04/140417101156.htm
International Union of Crystallography. "More effective kidney stone treatment, from macroscopic to nanoscale." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417101156.htm (accessed May 30, 2015).

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