Featured Research

from universities, journals, and other organizations

Diabetes duration, severity associated with brain atrophy

Date:
April 29, 2014
Source:
Radiological Society of North America
Summary:
Type 2 diabetes may be associated with brain degeneration, according to a new multi-center study. The study also found that, contrary to common clinical belief, diabetes may not be directly associated with small vessel ischemic disease, where the brain does not receive enough oxygenated blood.

Type 2 diabetes may be associated with brain degeneration, according to a new multicenter study published online in the journal Radiology. The study also found that, contrary to common clinical belief, diabetes may not be directly associated with small vessel ischemic disease, where the brain does not receive enough oxygenated blood.

"We found that patients having more severe diabetes had less brain tissue, suggesting brain atrophy," said lead author R. Nick Bryan, M.D., Ph.D., professor of radiology at the Perleman School of Medicine at the University of Pennsylvania. "They did not seem to have more vascular disease due to the direct effect of diabetes."

According the American Diabetes Association (ADA), nearly 26 million people in the United States have diabetes, and 1.9 million more are diagnosed with the disease each year. Type 2 is the most common form of diabetes. In type 2 diabetes, either the pancreas does not produce enough insulin or the cells ignore the insulin that is produced. The ADA estimates that, based on current trends, as many as one in three American adults will have diabetes in the year 2050.

"As diabetes becomes more common, better understanding of the disease and its management becomes even more important in order to minimize its effect on patient health," Dr. Bryan said.

For the study, Dr. Bryan and colleagues used magnetic resonance imaging (MRI) to investigate the association between severity and duration of type 2 diabetes mellitus and brain structure in 614 patients (mean age 62 years) at four participating centers (University of Minnesota, Minneapolis, Minn.; Wake Forest Medical School, Winston-Salem, N.C.; Columbia University, New York, N.Y.; and Case Western Reserve University, Cleveland, Ohio). The mean duration of disease in the study group was 9.9 years. The researchers specifically tested whether more severe diabetes was inversely correlated with brain volumes and positively correlated with ischemic lesion volumes.

The results showed that longer duration of diabetes was associated with brain volume loss, particularly in the gray matter. However, the study found no association of diabetes characteristics with small vessel ischemic disease in the brain.

"Diabetes duration correlated primarily with brain atrophy," Dr. Bryan said. "Stated another way, our results suggested that, for every 10 years of diabetes duration, the brain of a patient with diabetes looks approximately two years older than that of a non-diabetic person, in terms of gray matter volume."

The researchers noted that their findings may have implications for future decline of cognitive function in patients with diabetes and raise the possibility that such cognitive changes might not be strongly related to vascular dementia but to neurodegenerative disorders, such as Alzheimer's disease.


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Nick Bryan, Michel Bilello, Christos Davatzikos, Ronald M. Lazar, Anne Murray, Karen Horowitz, James Lovato, Michael E. Miller, Jeff Williamson, Lenore J. Launer. Effect of Diabetes on Brain Structure: The Action to Control Cardiovascular Risk in Diabetes MR Imaging Baseline Data. Radiology, 2014; 131494 DOI: 10.1148/radiol.14131494

Cite This Page:

Radiological Society of North America. "Diabetes duration, severity associated with brain atrophy." ScienceDaily. ScienceDaily, 29 April 2014. <www.sciencedaily.com/releases/2014/04/140429085552.htm>.
Radiological Society of North America. (2014, April 29). Diabetes duration, severity associated with brain atrophy. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2014/04/140429085552.htm
Radiological Society of North America. "Diabetes duration, severity associated with brain atrophy." ScienceDaily. www.sciencedaily.com/releases/2014/04/140429085552.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins