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A lab in your pocket: Using CAD to load dozens of tests on a lab-on-a-chip

Date:
May 7, 2014
Source:
Michigan Technological University
Summary:
Labs-on-a-chip hold huge promise for reducing the cost of medical diagnostics while expanding access to health care. Now scientists have developed software that would make them even more powerful: by enabling dozens of tests on a single biochip.

Two computer-generated configurations for routing a droplet through multiple lab-on-a-chip diagnostic tests, many more than are currently possible using manual methods. The software was developed by Michigan Tech's Shiyan Hu and Chen Liao. The figure is reproduced with permission of IEEE Transactions on NanoBioscience.
Credit: Chen Liao and Shiyan Hu

When you get sick, your physician may take a sample of your blood, send it to the lab and wait for results. In the near future, however, doctors may be able to run those tests almost instantly on a piece of plastic about the size of credit card.

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These labs-on-a-chip would not only be quick -- results are available in minutes -- but also inexpensive and portable. They could be used miles from the nearest medical clinic to test for anything from HIV to diabetes. But as powerful as they may be, they could be far better, says Shiyan Hu, an associate professor of electrical and computer engineering at Michigan Technological University.

Generally, a lab-on-a-chip (LOC) can run no more than a test or two. That's because the chips are designed manually, says Hu. If the LOC were made using computer-aided design, you could run dozens of tests with a single drop of blood.

"In a very short time, you could test for many conditions," he said. "This really would be an entire lab on a chip."

With PhD student Chen Liao, Hu has taken the first step. "We have developed software to design the hardware," he said. Their work focuses on routing the droplet of blood or other fluid through each test on the chip efficiently while avoiding any chip contamination.

"It has taken us four years to do the software, but to manufacture the LOC would be inexpensive," Hu said. "The materials are very cheap, and the results are more accurate than a conventional lab's."

Ultimately, Hu aims to fabricate their own biochip using their software.

Their work was featured on the cover of the March edition of IEEE Transactions on Nanobiosciences and described in the article "Physical-Level Synthesis for Digital Lab-On-a-Chip Considering Variation, Contamination, and Defect." Liao was partially supported by an A. Richard Newton Graduate Scholarship, awarded by the Design Automation Conference.


Story Source:

The above story is based on materials provided by Michigan Technological University. The original article was written by Marcia Goodrich. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen Liao, Shiyan Hu. Physical-Level Synthesis for Digital Lab-On-a-Chip Considering Variation, Contamination, and Defect. IEEE Transactions on NanoBioscience, 2014; 13 (1): 3 DOI: 10.1109/TNB.2013.2294943

Cite This Page:

Michigan Technological University. "A lab in your pocket: Using CAD to load dozens of tests on a lab-on-a-chip." ScienceDaily. ScienceDaily, 7 May 2014. <www.sciencedaily.com/releases/2014/05/140507212337.htm>.
Michigan Technological University. (2014, May 7). A lab in your pocket: Using CAD to load dozens of tests on a lab-on-a-chip. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2014/05/140507212337.htm
Michigan Technological University. "A lab in your pocket: Using CAD to load dozens of tests on a lab-on-a-chip." ScienceDaily. www.sciencedaily.com/releases/2014/05/140507212337.htm (accessed March 5, 2015).

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