Featured Research

from universities, journals, and other organizations

Important insights into carcinoma-associated fibroblasts

Date:
May 8, 2014
Source:
University of Notre Dame
Summary:
Important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology have been discovered by researchers. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood.

Carcinoma-associated fibroblasts (CAFs).
Credit: Image courtesy of University of Notre Dame

A new paper by a team of researchers led by Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame, offers important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood. In their new paper, Schafer and his fellow researchers describe a critical role for CAFs in blocking anoikis (a cell death process that inhibits the spread of tumor cells to distant sites) through the secretion of insulin-like growth factor-binding proteins (IGFBPs). They revealed the precise molecular mechanism utilized by IGFBPs to inhibit anoikis: the stabilization of an anti-cell death- protein called Mcl-1.

Related Articles


"While cells present in the tumor microenvironment are now widely appreciated to actively contribute to tumor progression, our studies have unveiled a novel mechanism by which this can occur," Schafer said. "Therapies designed to hinder this role for IGFBPs might be particularly useful in slowing breast cancer metastasis."

Schafer notes, however, that additional pre-clinical studies are necessary to better understand which IGFBPs might be amenable to target and to determine the precise point during tumor progression that IGBFP inhibition could be effective.


Story Source:

The above story is based on materials provided by University of Notre Dame. The original article was written by William G. Gilroy. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. J. Weigel, A. Jakimenko, B. A. Conti, S. E. Chapman, W. J. Kaliney, W. M. Leevy, M. M. Champion, Z. T. Schafer. CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis. Molecular Cancer Research, 2014; DOI: 10.1158/1541-7786.MCR-14-0090

Cite This Page:

University of Notre Dame. "Important insights into carcinoma-associated fibroblasts." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508111032.htm>.
University of Notre Dame. (2014, May 8). Important insights into carcinoma-associated fibroblasts. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2014/05/140508111032.htm
University of Notre Dame. "Important insights into carcinoma-associated fibroblasts." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508111032.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins