Featured Research

from universities, journals, and other organizations

Important insights into carcinoma-associated fibroblasts

Date:
May 8, 2014
Source:
University of Notre Dame
Summary:
Important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology have been discovered by researchers. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood.

Carcinoma-associated fibroblasts (CAFs).
Credit: Image courtesy of University of Notre Dame

A new paper by a team of researchers led by Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame, offers important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood. In their new paper, Schafer and his fellow researchers describe a critical role for CAFs in blocking anoikis (a cell death process that inhibits the spread of tumor cells to distant sites) through the secretion of insulin-like growth factor-binding proteins (IGFBPs). They revealed the precise molecular mechanism utilized by IGFBPs to inhibit anoikis: the stabilization of an anti-cell death- protein called Mcl-1.

Related Articles


"While cells present in the tumor microenvironment are now widely appreciated to actively contribute to tumor progression, our studies have unveiled a novel mechanism by which this can occur," Schafer said. "Therapies designed to hinder this role for IGFBPs might be particularly useful in slowing breast cancer metastasis."

Schafer notes, however, that additional pre-clinical studies are necessary to better understand which IGFBPs might be amenable to target and to determine the precise point during tumor progression that IGBFP inhibition could be effective.


Story Source:

The above story is based on materials provided by University of Notre Dame. The original article was written by William G. Gilroy. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. J. Weigel, A. Jakimenko, B. A. Conti, S. E. Chapman, W. J. Kaliney, W. M. Leevy, M. M. Champion, Z. T. Schafer. CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis. Molecular Cancer Research, 2014; DOI: 10.1158/1541-7786.MCR-14-0090

Cite This Page:

University of Notre Dame. "Important insights into carcinoma-associated fibroblasts." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508111032.htm>.
University of Notre Dame. (2014, May 8). Important insights into carcinoma-associated fibroblasts. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/05/140508111032.htm
University of Notre Dame. "Important insights into carcinoma-associated fibroblasts." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508111032.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins