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Predicting response to chemotherapy for triple-negative breast cancer patients: New method

Date:
May 14, 2014
Source:
University Hospitals Case Medical Center
Summary:
The presence of tumor-infiltrating lymphocytes, a type of white blood cell, ahead of treatment may help predict response to platinum-based chemotherapy in women with triple-negative breast cancer, research has shown. “Triple-negative breast cancers tend to be more aggressive compared to other types of breast cancers, and being able to predict response to therapy could greatly impact treatment decisions and patient outcomes,” says a study author.

Researchers from University Hospitals (UH) Case Medical Center's Seidman Cancer Center will present findings from a study that found the presence of tumor-infiltrating lymphocytes, a type of white blood cell, ahead of treatment may help predict response to platinum-based chemotherapy in women with triple-negative breast cancer. The data are being presented at the 50th American Society for Clinical Oncology (ASCO) Annual Meeting in Chicago.

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"Triple-negative breast cancers tend to be more aggressive compared to other types of breast cancers, and being able to predict response to therapy could greatly impact treatment decisions and patient outcomes," says study author Shaveta Vinayak, MD, oncologist at UH Case Medical Center and Assistant Professor at Case Western Reserve University School of Medicine. "Our research shows that the presence of lymphocytes before administering chemotherapy could predict a positive response to platinum-based therapy."

Triple negative breast cancers are those that do not have estrogen or progesterone receptors, and do not have an excess of the HER2 protein on the cancer cell surfaces. This makes it more difficult to treat because the hormone-blocking or the HER2-targeting treatments do not work. Triple negative breast cancers tend to occur more often in younger women and in African-American women.

Platinum-based therapies are being tested in clinical trials for triple-negative breast cancer, and evaluation of tumor-infiltrating lymphocytes is an important factor in determining response to this treatment. For oncologists, this could provide a new tool to individualize treatment for these women.


Story Source:

The above story is based on materials provided by University Hospitals Case Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Hospitals Case Medical Center. "Predicting response to chemotherapy for triple-negative breast cancer patients: New method." ScienceDaily. ScienceDaily, 14 May 2014. <www.sciencedaily.com/releases/2014/05/140514182534.htm>.
University Hospitals Case Medical Center. (2014, May 14). Predicting response to chemotherapy for triple-negative breast cancer patients: New method. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2014/05/140514182534.htm
University Hospitals Case Medical Center. "Predicting response to chemotherapy for triple-negative breast cancer patients: New method." ScienceDaily. www.sciencedaily.com/releases/2014/05/140514182534.htm (accessed November 23, 2014).

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