Featured Research

from universities, journals, and other organizations

New microRNAs found to be involved in regulation of BDNF levels

Date:
May 19, 2014
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
Brain Derived Neurotrophic Factor (BDNF) regulates many processes including memory and learning in our daily tasks. Levels of BDNF are important in determining the outcome of these processes. BDNF also carries strong potential to treat neurodegenerative diseases  which, among other things, affect memory and learning, such Alzheimer’s.

Brain Derived Neurotrophic Factor (BDNF) regulates many processes including memory and learning in our daily tasks. Levels of BDNF are important in determining the outcome of these processes. BDNF also carries strong potential to treat neurodegenerative diseases which, among other things, affect memory and learning, such Alzheimer's.

MicroRNA-206 was in 2012 shown to down-regulate BDNF levels. When in the animal model of Alzheimer's disease the activity of microRNA-206 was blocked, BDNF levels rose and Alzheimer's disease features were alleviated. This is an important discovery since to date drugs able to cure Alzheimer's disease do not exist.

A team lead by Academy Research Fellow Jaan-Olle Andressoo at the Institute of Biotechnology in University of Helsinki, Finland, screened for new microRNAs involved in the regulation of BDNF levels. The team identified four new microRNAs: microRNA-1, microRNA-10b, microRNA-155 and mcrioRNA-191, all of which were able to regulate BDNF levels.

"These results enable future studies in Alzheimer's and other disease models and highlight the importance of basic research which precedes drug-discovery," says Jaan-Olle Andressoo.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. Kärt Varendi, Anmol Kumar, Mari-Anne Härma, Jaan-Olle Andressoo. miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. Cellular and Molecular Life Sciences, 2014; DOI: 10.1007/s00018-014-1628-x

Cite This Page:

Helsingin yliopisto (University of Helsinki). "New microRNAs found to be involved in regulation of BDNF levels." ScienceDaily. ScienceDaily, 19 May 2014. <www.sciencedaily.com/releases/2014/05/140519090411.htm>.
Helsingin yliopisto (University of Helsinki). (2014, May 19). New microRNAs found to be involved in regulation of BDNF levels. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/05/140519090411.htm
Helsingin yliopisto (University of Helsinki). "New microRNAs found to be involved in regulation of BDNF levels." ScienceDaily. www.sciencedaily.com/releases/2014/05/140519090411.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) — It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) — According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins