Featured Research

from universities, journals, and other organizations

New perspectives to the design of molecular cages

Date:
May 26, 2014
Source:
Suomen Akatemia (Academy of Finland)
Summary:
Researchers report a new method of building molecular cages. The method involves the exploitation of intermolecular steric effects to control the outcome of a self-assembly reaction. Molecular cages are composed of organic molecules (ligands) which are bound to metal ions during a self-assembly process. Depending on the prevailing conditions, self-assembly processes urge to maximize the symmetry of the system and thus occupy every required metal binding site. The research group developed a method in which sterically hindered ligands are used to seemingly disrupt the self-assembly process. This new strategy allows a ligand to occupy only two of the four potential binding sites of the metal.

Researchers from the University of Jyväskylä report a new method of building molecular cages. The method involves the exploitation of intermolecular steric effects to control the outcome of a self-assembly reaction.

Molecular cages are composed of organic molecules (ligands) which are bound to metal ions during a self-assembly process. Depending on the prevailing conditions, self-assembly processes urge to maximize the symmetry of the system and thus occupy every required metal binding site. The research group led by docent Manu Lahtinen (University of Jyväskylä, Department of Chemistry) developed a method in which sterically hindered ligands are used to seemingly disrupt the self-assembly process. This new strategy allows a ligand to occupy only two of the four potential binding sites of the metal. The created molecular cage presents a low symmetric tetrahedral intermediate product in a reaction that would generally yield a higher symmetric octahedral cage.

The reported results provide new insights on how self-assembly processes of metal-organic systems can be controlled. However, the most significant feature of the proposed method is the new way of building molecular cages with vacant metal binding sites. This creates an opportunity to modify the properties and behavior of pre-assembled cages by incorporating functionally significant molecules to partially exposed metal ions. The presented strategy provides a new concept to build more complex molecular cages.

Molecular cages are the materials of tomorrow

Molecular cages and capsules are hollow nano-sized (1 x 10-9 m) compounds that consist of organic molecules or ions and, in most cases, metal ions. They share many structural features with, for example, viruses whose shells (capsids) are composed of organized proteins. One of the most significant feature of molecular cages is their ability to bind and release guest molecules depending on the prevailing conditions. Hence, some of their most important potential applications include biomedicinal uses (transport of drugs), storing of unstable and/or reactive molecules and recovery of hazardous compounds from aquatic environment.

The present study was published in the journal Chemical Communications and is part of M.Sc. Anssi Peuronen's doctoral thesis that focuses on the study of structural chemistry of cationic ammonium compounds and is supervised by Docent Manu Lahtinen. The third member of the research group is M.Sc. student Samu Forsblom.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal Reference:

  1. Anssi Peuronen, Samu Forsblom, Manu Lahtinen. Sterically controlled self-assembly of tetrahedral M6L4 cages via cationic N-donor ligands. Chemical Communications, 2014; 50 (41): 5469 DOI: 10.1039/C3CC49663E

Cite This Page:

Suomen Akatemia (Academy of Finland). "New perspectives to the design of molecular cages." ScienceDaily. ScienceDaily, 26 May 2014. <www.sciencedaily.com/releases/2014/05/140526101654.htm>.
Suomen Akatemia (Academy of Finland). (2014, May 26). New perspectives to the design of molecular cages. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2014/05/140526101654.htm
Suomen Akatemia (Academy of Finland). "New perspectives to the design of molecular cages." ScienceDaily. www.sciencedaily.com/releases/2014/05/140526101654.htm (accessed July 24, 2014).

Share This




More Matter & Energy News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) — 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Boeing Ups Outlook on 52% Profit Jump

Boeing Ups Outlook on 52% Profit Jump

Reuters - Business Video Online (July 23, 2014) — Commercial aircraft deliveries rose seven percent at Boeing, prompting the aerospace company to boost full-year profit guidance- though quarterly revenues missed analyst estimates. Bobbi Rebell reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Car Market on the Rebound?

Europe's Car Market on the Rebound?

Reuters - Business Video Online (July 23, 2014) — Daimler kicks off a round of second-quarter earnings results from Europe's top carmakers with a healthy set of numbers - prompting hopes that stronger sales in Europe will counter weakness in emerging markets. Hayley Platt reports. Video provided by Reuters
Powered by NewsLook.com
9/11 Commission Members Warn of Terror "fatigue" Among American Public

9/11 Commission Members Warn of Terror "fatigue" Among American Public

Reuters - US Online Video (July 22, 2014) — Ten years after releasing its initial report, members of the 9/11 Commission warn of the "waning sense of urgency" in combating terrorists attacks. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins