Featured Research

from universities, journals, and other organizations

Significant side effects experienced by BRCA mutation carriers following cancer risk-reducing surgical procedure

Date:
May 30, 2014
Source:
Perelman School of Medicine at the University of Pennsylvania
Summary:
The majority of women with cancer causing BRCA1 and BRCA2 mutations experience sexual dysfunction, menopausal symptoms, cognitive and stress issues, and poor sleep following prophylactic removal of their Fallopian tubes and ovaries -- a procedure known as risk-reducing salpingo-oophorectomy (RRSO) -- according to results of a new study.

The majority of women with cancer causing BRCA1 and BRCA2 mutations experience sexual dysfunction, menopausal symptoms, cognitive and stress issues, and poor sleep following prophylactic removal of their Fallopian tubes and ovaries -- a procedure known as risk-reducing salpingo-oophorectomy (RRSO) -- according to results of a new study from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania. The team's findings, which reaffirm the need for a better understanding of how to manage long-term effects of the risk-reducing procedure, will be presented during the annual meeting of the American Society of Clinical Oncology in Chicago's McCormick Place on Saturday, May 31, 2014.

Related Articles


"These results reinforce the need for care providers to better understand and communicate with patients about the possible long-term effects of bilateral RRSO," said lead author Susan Domchek, MD, director of Penn's Basser Research Center for BRCA. "Removal of the Fallopian tubes and ovaries is associated with a decreased risk of death from breast and ovarian cancer for BRCA carriers, and is one of the most important interventions we have at the current time. However, this procedure comes with a price, so it's extremely important that clinicians work with women to help alleviate symptoms."

The new study surveyed 637 women with BRCA1 or BRCA2 mutations who had undergone the risk-reducing surgical procedure to have both ovaries and Fallopian tubes removed. Domchek and colleagues assessed participant quality-of-life through a series of questionnaires. Results show that suboptimal scores were present in the majority of patients for the majority of measures. Specifically, 73 percent reported sexual dysfunction, such as the absence of satisfaction and presence of pain; 61 percent had problems sleeping; 57 percent had symptoms of menopause such as hot flashes and vaginal dryness; and 56 percent had elevated levels of stress. Hormone replacement therapy did help mitigate symptoms, particularly in women undergoing oophorectomy prior to age 50.

Currently, it is recommended that BRCA1/2 mutation carriers undergo oophorectomy between ages 35-40 given the substantial benefits in decreasing breast and ovarian cancer risk and improving overall survival. "Our work highlights the need for novel strategies to prevent breast and ovarian cancer. Despite the efficacy of oophorectomy, given the negative impact, we need to continue to strive towards other options for prevention."


Story Source:

The above story is based on materials provided by Perelman School of Medicine at the University of Pennsylvania. Note: Materials may be edited for content and length.


Cite This Page:

Perelman School of Medicine at the University of Pennsylvania. "Significant side effects experienced by BRCA mutation carriers following cancer risk-reducing surgical procedure." ScienceDaily. ScienceDaily, 30 May 2014. <www.sciencedaily.com/releases/2014/05/140530121349.htm>.
Perelman School of Medicine at the University of Pennsylvania. (2014, May 30). Significant side effects experienced by BRCA mutation carriers following cancer risk-reducing surgical procedure. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2014/05/140530121349.htm
Perelman School of Medicine at the University of Pennsylvania. "Significant side effects experienced by BRCA mutation carriers following cancer risk-reducing surgical procedure." ScienceDaily. www.sciencedaily.com/releases/2014/05/140530121349.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins