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Healthy tissue grafted to brains of Huntington's patients also develops the disease

Date:
June 5, 2014
Source:
Université Laval
Summary:
Healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft, a study shows. This discovery will have profound implications on our understanding of the disease and how to treat it, and may also lead to the development of new therapies for neurodegenerative disorders.
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FULL STORY

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft. This discovery will have profound implications on our understanding of the disease and how to treat it, and may also lead to the development of new therapies for neurodegenerative disorders.

Huntington's disease is a hereditary illness that causes the progressive breakdown of nerve cells in the brain, resulting in major motor, cognitive, and psychiatric impairments. It leads to a gradual loss of autonomy and, eventually, to death. The disease typically appears between age 40 and 50. There is no cure and current treatment methods only help control some of the symptoms without slowing down the disease itself.

"Until now, we thought that Huntington's disease was exclusively the result of a genetic mutation within cells, an intrinsic phenomenon that gradually led to the manifestation of the illness," explains Francesca Cicchetti, professor at the Université Laval Faculty of Medicine, researcher at the CHU de Québec Research Center, and lead author of the study. "However, our work shows that the mutant protein at the source of the illness can also spread from sick to healthy cells, which we did not expect."

These findings by Dr. Cicchetti and her colleagues will have profound implications on the understanding of this pathology and how to treat it. It could also lead to the development of new therapies against other more common neurodegenerative disorders of the central nervous system, as well as diseases related to the propagation of pathological proteins, including Parkinson's and Alzheimer's.


Story Source:

The above post is reprinted from materials provided by Université Laval. Note: Materials may be edited for content and length.


Journal Reference:

  1. F Cicchetti, S Lacroix, G Cisbani, N Vallières, M Saint-Pierre, I St-Amour, R Tolouei, JN Skepper, RA Hauser, D Mantovani, RA Barker, TB Freeman. Mutant huntingtin is present in neuronal grafts in Huntington's disease patients. Annals of Neurology, 2014; DOI: 10.1002/ana.24174

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Université Laval. "Healthy tissue grafted to brains of Huntington's patients also develops the disease." ScienceDaily. ScienceDaily, 5 June 2014. <www.sciencedaily.com/releases/2014/06/140605093309.htm>.
Université Laval. (2014, June 5). Healthy tissue grafted to brains of Huntington's patients also develops the disease. ScienceDaily. Retrieved July 31, 2015 from www.sciencedaily.com/releases/2014/06/140605093309.htm
Université Laval. "Healthy tissue grafted to brains of Huntington's patients also develops the disease." ScienceDaily. www.sciencedaily.com/releases/2014/06/140605093309.htm (accessed July 31, 2015).

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