Featured Research

from universities, journals, and other organizations

Experts unlock key to blood vessel repair

Date:
June 10, 2014
Source:
University of Leeds
Summary:
A way to restore the function of damaged blood vessel repairing cells has been deciphered by scientists. The findings have also identified a potential reason why South Asian men in the UK experience an increased risk of heart disease. "This research gives hope that in the future it may be possible to enhance blood vessel repair by targeting these proteins. Knowing how to improve blood supply could one day help to mend hearts damaged after a heart attack," researchers conclude.

Scientists from the University of Leeds have found a way to restore the function of damaged blood vessel repairing cells, in a potentially important step for the future treatment of heart disease.

The research, part-funded by the British Heart Foundation (BHF), could also pave the way for new targets for drug development in the fight against heart disease.

The findings have also identified a potential reason why South Asian men in the UK experience an increased risk of heart disease.

Led by Dr Richard Cubbon in the School of Medicine, the research team studied cells which can be grown in test tubes from routine blood samples (called outgrowth endothelial cells, or OEC), that can repair damaged blood vessels, or even form new ones.

Using a variety of experimental models which mimicked cardiovascular diseases, the researchers showed that cells grown from apparently healthy young South Asian men were effectively unable to repair damaged blood vessels or form new blood vessels in damaged tissues, compared to a matched control group of white European men.

The team then identified a protein, called Akt, known to be important in blood vessel formation, which was much less active in the South Asian men's cells. By adding active Akt back into their OEC using specially-designed viruses, it was possible to completely restore the ability of these cells to repair vessels.

Dr Cubbon said: "Our work provides a proof of principle that it is possible to restore the blood vessel healing properties of cells, which might be suitable for use as a treatment.

"By understanding why Akt is less active in these cells, we may gain a better understanding of why South Asian men are prone to cardiovascular disease, and possibly find new targets for drug development."

Dr Shannon Amoils, Senior Researcher Advisor at the BHF, which helped to fund the study, said: "We already know that people of South Asian ethnicity are at a higher risk of cardiovascular disease. In their latest study Dr Cubbon and his colleagues have found one possible reason for this increased risk. The study showed that cells involved in the repair of blood vessels may not work as well in some South Asian people because of low levels of proteins involved in the healing process.

"This research gives hope that in the future it may be possible to enhance blood vessel repair by targeting these proteins. Knowing how to improve blood supply could one day help to mend hearts damaged after a heart attack -- the focus of our Mending Broken Hearts Appeal."


Story Source:

The above story is based on materials provided by University of Leeds. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richard M Cubbon, Nadira Y Yuldasheva, Hema Viswambharan, Ben N Mercer, Vivek Baliga, Sam L Stephen, Jonathan Askham, Piruthivi Sukumar, Anna Skromna, Romana S Mughal, Andrew M.N. Walker, Alexander Bruns, Marc A Bailey, Stacey Galloway, Helen Imrie, Matthew C Gage, Mark Rakobowchuk, Jing Li, Karen E Porter, Sreenivasan Ponnambalam, Stephen B Wheatcroft, David J Beech, Mark T Kearney. Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. STEM CELLS, 2014; DOI: 10.1002/stem.1766

Cite This Page:

University of Leeds. "Experts unlock key to blood vessel repair." ScienceDaily. ScienceDaily, 10 June 2014. <www.sciencedaily.com/releases/2014/06/140610205400.htm>.
University of Leeds. (2014, June 10). Experts unlock key to blood vessel repair. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/06/140610205400.htm
University of Leeds. "Experts unlock key to blood vessel repair." ScienceDaily. www.sciencedaily.com/releases/2014/06/140610205400.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins