Featured Research

from universities, journals, and other organizations

Unlocking therapeutic potential of SLC13 transporters

Date:
June 18, 2014
Source:
The Rockefeller University Press
Summary:
The first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan, has been completed, potentially providing the key that will enable researchers to unlock their therapeutic potential. Members of the SLC13 transporter family play a key role in the regulation of fat storage, insulin resistance, and other processes.

Researchers analyzed the functional properties of VcINDY (pictured), laying the groundwork for future studies of a family of transporters implicated in diabetes, obesity, and lifespan.
Credit: Mulligan et al., 2014; structure from Protein Data Bank accession no. 4F35

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

Members of the SLC13 transporter family play a key role in the regulation of fat storage, insulin resistance, and other processes. Some SLC13 transporters mediate the transport of Krebs cycle intermediates -- compounds essential for the body's metabolic activity -- across the cell membrane. Previous studies have shown that loss of one member of this family protects mice against obesity and insulin resistance, and loss of another results in reduced fat storage and extended lifespan in fruit flies. These findings hint at the therapeutic potential of targeting these transporters to combat metabolic disease, obesity, diabetes, and other conditions.

A recently obtained high-resolution structure of VcINDY -- a member of the SLC13 family found in the bacteria that causes cholera -- has provided key structural insights, but understanding how these transporters function at the cellular level remains a mystery. To find out more, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) reconstituted VcINDY into small synthetic vesicles called liposomes that allowed them to monitor its activity in isolation. Led by Joseph Mindell, the team was thereby able to analyze the properties of VcINDY as a transporter and provide a model that lays the groundwork for future studies of SLC13 transporters, potentially providing the key that will enable researchers to unlock their therapeutic potential.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Mulligan, G. A. Fitzgerald, D.-N. Wang, J. A. Mindell. Functional characterization of a Na -dependent dicarboxylate transporter from Vibrio cholerae. The Journal of General Physiology, 2014; 143 (6): 745 DOI: 10.1085/jgp.201311141

Cite This Page:

The Rockefeller University Press. "Unlocking therapeutic potential of SLC13 transporters." ScienceDaily. ScienceDaily, 18 June 2014. <www.sciencedaily.com/releases/2014/06/140618135838.htm>.
The Rockefeller University Press. (2014, June 18). Unlocking therapeutic potential of SLC13 transporters. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/06/140618135838.htm
The Rockefeller University Press. "Unlocking therapeutic potential of SLC13 transporters." ScienceDaily. www.sciencedaily.com/releases/2014/06/140618135838.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins