Featured Research

from universities, journals, and other organizations

BPA exposure during fetal development raises risk of precancerous prostate lesions later in life

Date:
June 23, 2014
Source:
Endocrine Society
Summary:
The endocrine-disrupting chemical bisphenol A (BPA) reprograms the developing prostate, making the gland more susceptible to precancerous lesions and other diseases later in a man’s life, a new study has found for the first time. BPA is a chemical used to manufacture certain plastics and is often found in water bottles, food storage containers and other consumer products. BPA disrupts the normal functioning of the body's hormones by mimicking the hormone estrogen.

A new study has found for the first time that the endocrine-disrupting chemical bisphenol A (BPA) reprograms the developing prostate, making the gland more susceptible to precancerous lesions and other diseases later in a man's life. The results will be reported at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

"By using two novel models of human prostate development involving embryonic stem cells, this study is the first to show that low doses of BPA can actually reprogram human fetal prostate tissue in a manner that raises the risk of prostate diseases as men age," said the study's presenting author, Esther Calderon-Gierszal, a PhD student at the University of Illinois at Chicago, Chicago, IL.

BPA is a chemical used to manufacture certain plastics and is often found in water bottles, food storage containers and other consumer products. BPA disrupts the normal functioning of the body's hormones by mimicking the hormone estrogen.

Past studies of adult prostate stem cells and animal models found that BPA exposure increased the risk of developing prostate cancer, so researchers at the University of Chicago at Illinois set out to examine the effect in human embryonic prostate cells. The study was the first to generate a human fetal prostate model grown in a dish in a laboratory. In addition, researchers developed a human-like model in a mouse to study the effects of BPA on the developing prostate.

When the human fetal prostate model grown in the laboratory was exposure to low doses of BPA, investigators reported that exposure altered fetal prostate formation and increased the number of stem cells in the adult prostate, which could lead to aberrant growth and disease with aging. This type of cell activity eventually could lead to the development of prostate cancer.

To observe the effects of BPA in prostate tissue grown in a host mouse, researchers combined human embryonic stem cells and rat cells called mesenchyme. The researchers then grafted the combined tissue on to the kidneys of mice where it developed into human-like prostate tissue. The experiment modeled human BPA exposure feeding the mice low-dose BPA which led to the development of lesions in the human prostate tissue, including a precancerous lesion known as prostate intraepithelial neoplasia, or PIN.

"Using human embryonic stem cells to generate prostate tissues, we were able to document the direct effect low-dose BPA exposure had in driving prostate pathology and disease," Calderon-Gierszal said.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "BPA exposure during fetal development raises risk of precancerous prostate lesions later in life." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623091955.htm>.
Endocrine Society. (2014, June 23). BPA exposure during fetal development raises risk of precancerous prostate lesions later in life. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2014/06/140623091955.htm
Endocrine Society. "BPA exposure during fetal development raises risk of precancerous prostate lesions later in life." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623091955.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins