Featured Research

from universities, journals, and other organizations

Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes

Date:
June 23, 2014
Source:
Diabetologia
Summary:
Calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes, new research shows. Gestational diabetes mellitus (GDM), a pregnancy complication, is characterized by carbohydrate intolerance and metabolic disorders. Approximately 7% of all pregnancies in the United States are affected by GDM, but the prevalence ranges from 1 to 14% of all pregnancies in the world depending on the population studied and the diagnostic criteria used.

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes. The research is by Dr Ahmad Esmaillzadeh, Isfahan University of Medical Sciences, Isfahan, Iran, and colleagues.

Related Articles


Gestational diabetes mellitus (GDM), a pregnancy complication, is characterized by carbohydrate intolerance and metabolic disorders. Approximately 7% of all pregnancies in the United States are affected by GDM, but the prevalence ranges from 1 to 14% of all pregnancies in the world depending on the population studied and the diagnostic criteria used. GDM can increase the risk of pre-eclampsia, pre-term delivery and delivery by caesarean section.

"We are aware of no study that has examined the effect of joint calcium-vitamin D supplementation on insulin function, lipid profiles, inflammatory factors and biomarkers of oxidative stress in GDM," say the authors. "The current study was, therefore, done to investigate the effects of calcium plus vitamin D supplementation on metabolic status of pregnant women with GDM."

This randomised placebo-controlled trial was performed on 56 women with GDM. Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. Individuals in the calcium-vitamin D group (n=28) received 1000 mg calcium per day and 50000 IU (international units) vitamin D3 tablets two times during the study (at study baseline and day 21 of intervention) and those in the placebo group (n=28) received two placebos at the same time points. Fasting blood samples were taken at study baseline and after 6 weeks of intervention.

The authors found that, following the administration of calcium plus vitamin D supplements, they observed significant reductions in fasting plasma glucose, insulin, and LDL or 'bad' cholesterol, as well as improvements in insulin sensitivity and increases in HDL or 'good' cholesterol, compared with those patients who took placebo.

The authors say: "Calcium plus vitamin D supplementation in GDM women had beneficial effects on metabolic profile...this is important because elevated circulating levels of inflammatory markers and impaired insulin metabolism in GDM can predict the progression to type 2 diabetes (T2D) later in life and neonatal complications. Impaired insulin metabolism in women with GDM can result in adverse long term maternal outcomes and increased perinatal morbidity (babies large for gestational age, birth trauma, pre-eclampsia), and long-term consequences in the offspring. In addition, increased inflammatory markers in GDM might predict the future development of both metabolic and cardiovascular disease."


Story Source:

The above story is based on materials provided by Diabetologia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zatollah Asemi, Maryam Karamali, Ahmad Esmaillzadeh. Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial. Diabetologia, 2014; DOI: 10.1007/s00125-014-3293-x

Cite This Page:

Diabetologia. "Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623225005.htm>.
Diabetologia. (2014, June 23). Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2014/06/140623225005.htm
Diabetologia. "Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623225005.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins