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Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes

Date:
June 23, 2014
Source:
Diabetologia
Summary:
Calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes, new research shows. Gestational diabetes mellitus (GDM), a pregnancy complication, is characterized by carbohydrate intolerance and metabolic disorders. Approximately 7% of all pregnancies in the United States are affected by GDM, but the prevalence ranges from 1 to 14% of all pregnancies in the world depending on the population studied and the diagnostic criteria used.

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes. The research is by Dr Ahmad Esmaillzadeh, Isfahan University of Medical Sciences, Isfahan, Iran, and colleagues.

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Gestational diabetes mellitus (GDM), a pregnancy complication, is characterized by carbohydrate intolerance and metabolic disorders. Approximately 7% of all pregnancies in the United States are affected by GDM, but the prevalence ranges from 1 to 14% of all pregnancies in the world depending on the population studied and the diagnostic criteria used. GDM can increase the risk of pre-eclampsia, pre-term delivery and delivery by caesarean section.

"We are aware of no study that has examined the effect of joint calcium-vitamin D supplementation on insulin function, lipid profiles, inflammatory factors and biomarkers of oxidative stress in GDM," say the authors. "The current study was, therefore, done to investigate the effects of calcium plus vitamin D supplementation on metabolic status of pregnant women with GDM."

This randomised placebo-controlled trial was performed on 56 women with GDM. Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. Individuals in the calcium-vitamin D group (n=28) received 1000 mg calcium per day and 50000 IU (international units) vitamin D3 tablets two times during the study (at study baseline and day 21 of intervention) and those in the placebo group (n=28) received two placebos at the same time points. Fasting blood samples were taken at study baseline and after 6 weeks of intervention.

The authors found that, following the administration of calcium plus vitamin D supplements, they observed significant reductions in fasting plasma glucose, insulin, and LDL or 'bad' cholesterol, as well as improvements in insulin sensitivity and increases in HDL or 'good' cholesterol, compared with those patients who took placebo.

The authors say: "Calcium plus vitamin D supplementation in GDM women had beneficial effects on metabolic profile...this is important because elevated circulating levels of inflammatory markers and impaired insulin metabolism in GDM can predict the progression to type 2 diabetes (T2D) later in life and neonatal complications. Impaired insulin metabolism in women with GDM can result in adverse long term maternal outcomes and increased perinatal morbidity (babies large for gestational age, birth trauma, pre-eclampsia), and long-term consequences in the offspring. In addition, increased inflammatory markers in GDM might predict the future development of both metabolic and cardiovascular disease."


Story Source:

The above story is based on materials provided by Diabetologia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zatollah Asemi, Maryam Karamali, Ahmad Esmaillzadeh. Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial. Diabetologia, 2014; DOI: 10.1007/s00125-014-3293-x

Cite This Page:

Diabetologia. "Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623225005.htm>.
Diabetologia. (2014, June 23). Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/06/140623225005.htm
Diabetologia. "Calcium, vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623225005.htm (accessed November 27, 2014).

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