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Common treatment of Sjögren syndrome does not appear effective

Date:
July 15, 2014
Source:
JAMA - Journal of the American Medical Association
Summary:
Among patients with the systemic autoimmune disease primary Sjögren syndrome, use of hydroxychloroquine, the most frequently prescribed treatment for the disorder, did not improve symptoms during 24 weeks of treatment compared with placebo, according to a study. Primary Sjögren syndrome is characterized by mouth and eye dryness, pain, and fatigue, with systemic manifestations occurring in approximately one-third of patients.

Among patients with the systemic autoimmune disease primary Sjögren syndrome, use of hydroxychloroquine, the most frequently prescribed treatment for the disorder, did not improve symptoms during 24 weeks of treatment compared with placebo, according to a study in the July 16 issue of JAMA.

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Primary Sjögren syndrome is characterized by mouth and eye dryness, pain, and fatigue, with systemic manifestations occurring in approximately one-third of patients. Despite the wide use of hydroxychloroquine in clinical practice, evidence regarding its efficacy is limited, according to background information in the article.

Jacques-Eric Gottenberg, M.D., Ph.D., of the Universite de Strasbourg, Strasbourg, France, and colleagues randomly assigned 120 patients with primary Sjögren syndrome to receive hydroxychloroquine or placebo for 24 weeks. All patients (treatment and placebo) were prescribed hydroxychloroquine between weeks 24 and 48. The study was conducted at 15 university hospitals in France.

At 24 weeks, the proportion of patients meeting the primary end point (30 percent or greater reduction in 2 of 3 scores evaluating dryness, pain, and fatigue) was 17.9 percent (10/56) in the hydroxychloroquine group and 17.2 percent (11/64) in the placebo group. Use of hydroxychloroquine was also not associated with improvement in certain lab tests used to monitor the activity of Sjögren (anti-SSA antibodies, IgG levels). During the first 24 weeks, there were 2 serious adverse events in the hydroxychloroquine group and 3 in the placebo group. In the last 24 weeks, there were 3 in the hydroxychloroquine group and 4 in the placebo group.

"In the present study, hydroxychloroquine did not demonstrate efficacy for the main disabling symptoms -- dryness, pain, and fatigue -- of primary Sjögren syndrome compared with placebo. [This trial] extends the negative results of the only previous controlled crossover trial, which included 19 patients and confirms that previous open trials might have overestimated the therapeutic efficacy of hydroxychloroquine in primary Sjögren syndrome," the authors write.

"Further studies are needed to evaluate longer-term outcomes," researchers say.


Story Source:

The above story is based on materials provided by JAMA - Journal of the American Medical Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jacques-Eric Gottenberg, Philippe Ravaud, Xavier Puéchal, Véronique Le Guern, Jean Sibilia, Vincent Goeb, Claire Larroche, Jean-Jacques Dubost, Stéphanie Rist, Alain Saraux, Valérie Devauchelle-Pensec, Jacques Morel, Gilles Hayem, Pierre Hatron, Aleth Perdriger, Damien Sene, Charles Zarnitsky, Djilali Batouche, Valérie Furlan, Joelle Benessiano, Elodie Perrodeau, Raphaele Seror, Xavier Mariette. Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome. JAMA, 2014; 312 (3): 249 DOI: 10.1001/jama.2014.7682

Cite This Page:

JAMA - Journal of the American Medical Association. "Common treatment of Sjögren syndrome does not appear effective." ScienceDaily. ScienceDaily, 15 July 2014. <www.sciencedaily.com/releases/2014/07/140715165817.htm>.
JAMA - Journal of the American Medical Association. (2014, July 15). Common treatment of Sjögren syndrome does not appear effective. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2014/07/140715165817.htm
JAMA - Journal of the American Medical Association. "Common treatment of Sjögren syndrome does not appear effective." ScienceDaily. www.sciencedaily.com/releases/2014/07/140715165817.htm (accessed February 28, 2015).

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