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Showers may be linked to Crohn's disease, say researchers

Date:
July 23, 2014
Source:
Lancaster University
Summary:
Mycobacterium avium subspecies paratuberculosis (Map) is a bacterial pathogen that causes Johne’s disease in animals, particularly cattle, and is significantly associated with Crohn’s disease (CD) in humans, both chronic inflammatory conditions, mainly of the intestine. This is the first study to provide evidence that fine water spray from both domestic showers and rivers is an exposure route for the bacteria to humans and may play a role in the development of Crohn’s Disease.

Humans may be exposed to bacteria linked with Crohn’s disease through fine spray from showers and rivers according to research led by Lancaster University.

Mycobacterium avium subspecies paratuberculosis (Map) is a bacterial pathogen that causes Johne’s disease in animals, particularly cattle, and is significantly associated with Crohn’s disease (CD) in humans, both chronic inflammatory conditions, mainly of the intestine.

This is the first study – published in Pathogens - to provide evidence that fine water spray from both domestic showers and rivers is an exposure route for the bacteria to humans and may play a role in the development of Crohn’s Disease.

Professor Roger Pickup from Lancaster University’s Faculty of Health and Medicine led the collaborative research partnership together with the NERC Centre for Ecology and Hydrology at Lancaster, Royal Lancaster Infirmary, Cardiff University and Kings College London.

The team examined domestic showers from different regions in the U.K. and detected Map in three out of 30 independent samples, providing a route for human exposure by fine water spray.

Professor Pickup said: “We recommend that in line with precautions against Legionnaires’ Disease, that showers should be run for a short period before use, particularly those that have not been used for a while.”

Previous studies by the same team have shown the Map bacteria to be present in UK rivers due to land deposition from chronic livestock infection and runoff driven by rainfall.

They also found Map bacteria in five aerosol samples collected above the River Taff in Wales.

The researchers said it was possible that that the significant clusters of Crohn’s Disease patients in Cardiff are, in part, due to inhalation of Map in fine water spray generated from the river and presented by the prevailing winds.

Inhalation has been shown as a route for the infection of cattle and lung involvement is well described in adults with Crohn’s disease; the disease in children often begins with a cough and a mild inflammation of the throat and lungs. Initial invasion via the oral route followed by Map’s substantial tissue tropism for the gut may result in chronic inflammation of the intestine.

Although Map is difficult in to detect humans and even more difficult to culture, recent data has shown it to be significantly associated with Crohn’s disease and, if appropriate tests are done correctly, that almost everyone with chronic inflammation of the gut of the Crohn’s disease type is found to be infected with this chronic enteric pathogen.


Story Source:

The above story is based on materials provided by Lancaster University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Glenn Rhodes, Hollian Richardson, John Hermon-Taylor, Andrew Weightman, Andrew Higham, Roger Pickup. Mycobacterium avium Subspecies paratuberculosis: Human Exposure through Environmental and Domestic Aerosols. Pathogens, 2014; 3 (3): 577 DOI: 10.3390/pathogens3030577

Cite This Page:

Lancaster University. "Showers may be linked to Crohn's disease, say researchers." ScienceDaily. ScienceDaily, 23 July 2014. <www.sciencedaily.com/releases/2014/07/140723114027.htm>.
Lancaster University. (2014, July 23). Showers may be linked to Crohn's disease, say researchers. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/07/140723114027.htm
Lancaster University. "Showers may be linked to Crohn's disease, say researchers." ScienceDaily. www.sciencedaily.com/releases/2014/07/140723114027.htm (accessed October 20, 2014).

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