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Reduction of tau protein improves symptoms in model of severe childhood epilepsy

Date:
August 13, 2014
Source:
Gladstone Institutes
Summary:
Reducing brain levels of the protein tau effectively blocks the development of disease in a mouse model of Dravet syndrome, a severe intractable form of childhood epilepsy, researchers report. Dravet syndrome is one of the most challenging forms of childhood epilepsy, resulting from a specific genetic mutation that affects sodium channels in the brain. Frequent, relentless seizures are accompanied by cognitive impairments and behavioral problems similar to autism, and up to 20% of patients succumb to sudden death.

Researchers at the Gladstone Institutes have shown that reducing brain levels of the protein tau effectively blocks the development of disease in a mouse model of Dravet syndrome, a severe intractable form of childhood epilepsy. This therapeutic strategy not only suppressed seizure activity and premature death, but also improved cognitive and behavioral abnormalities that can accompany this syndrome.

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Previous studies from this group have shown that lowering tau levels reduces abnormal brain activity in models of Alzheimer's disease, but this is the first demonstration that tau reduction may also be beneficial in intractable genetic epilepsy.

"It would really be wonderful if tau reduction turned out to be useful not only in Alzheimer's disease, but also in other disabling neurological conditions for which there currently are no effective treatments," said senior author Lennart Mucke, MD, the director of the Gladstone Institute of Neurological Disease and a professor of Neurology and Neuroscience at the University of California, San Francisco. "We suspected that this approach might be beneficial in Dravet, but we couldn't be sure because of the severity of this syndrome and the corresponding model. We are thrilled that our strategy was so effective, but a lot more work is needed to advance it into the clinic."

Dravet syndrome is one of the most challenging forms of childhood epilepsy, resulting from a specific genetic mutation that affects sodium channels in the brain. Frequent, relentless seizures are accompanied by cognitive impairments and behavioral problems similar to autism, and up to 20% of patients succumb to sudden death. Current treatments for Dravet syndrome are largely ineffective, making research into the disorder particularly urgent.

"I am especially excited about the improvements we observed in cognitive and behavioral dysfunctions because these abnormalities are particularly hard on the kids -- and their parents," said first author Ania Gheyara, MD, PhD, a staff scientist at Gladstone who is also affiliated with the UCSF Department of Pathology. "Our hope is that this approach will be broadly applicable to many different types of epilepsy."

In the study, which was published online in the Annals of Neurology, the scientists reduced the level of the protein tau by genetically engineering Dravet mouse models, "knocking out" the gene associated with tau production. The deletion of one copy of the gene resulted in substantial improvements in most symptoms, while deleting both copies eliminated them almost completely. This included a significant reduction in both spontaneous and heat-induced seizures. The latter were used to mimic the fever-related seizures that are often seen in the early stages of Dravet syndrome. Network activity in the brain was also normalized, providing additional support for the remarkable ability of tau reduction to suppress epileptic activity.

Additionally, tau reduction ameliorated the learning and memory deficits and behavioral abnormalities present in the Dravet mice, which may relate to the cognitive impairments and autism-like behaviors seen in the human condition.

"The next steps are to develop tau-lowering therapeutics that could be used in humans and to evaluate their safety and efficacy in preclinical studies," said Dr. Mucke, "objectives we are pursuing actively."


Story Source:

The above story is based on materials provided by Gladstone Institutes. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ania L. Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J. Craft, Kaitlyn Ho, Weikun Guo, Mariel M. Finucane, Pascal E. Sanchez, Lennart Mucke. Tau reduction prevents disease in a mouse model of Dravet syndrome. Annals of Neurology, 2014; DOI: 10.1002/ana.24230

Cite This Page:

Gladstone Institutes. "Reduction of tau protein improves symptoms in model of severe childhood epilepsy." ScienceDaily. ScienceDaily, 13 August 2014. <www.sciencedaily.com/releases/2014/08/140813103657.htm>.
Gladstone Institutes. (2014, August 13). Reduction of tau protein improves symptoms in model of severe childhood epilepsy. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/08/140813103657.htm
Gladstone Institutes. "Reduction of tau protein improves symptoms in model of severe childhood epilepsy." ScienceDaily. www.sciencedaily.com/releases/2014/08/140813103657.htm (accessed November 28, 2014).

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