Featured Research

from universities, journals, and other organizations

High-dose flu vaccine more effective in elderly, study finds

Date:
August 13, 2014
Source:
Vanderbilt University Medical Center
Summary:
High-dose influenza vaccine is 24 percent more effective than the standard-dose vaccine in protecting persons ages 65 and over against influenza illness and its complications, according to a study.

High-dose influenza vaccine is 24 percent more effective than the standard-dose vaccine in protecting persons ages 65 and over against influenza illness and its complications, according to a Vanderbilt-led study published today in the New England Journal of Medicine (NEJM).

The multi-center study enrolled 31,989 participants from 126 research centers in the U.S. and Canada during the 2011-2012 and 2012-2013 influenza seasons in the Northern Hemisphere in order to compare the high-dose trivalent vaccine versus the standard-dose trivalent vaccine in adults over 65 years of age.

"The study was done to see if using a high-dose vaccine protected older adults better than the usual vaccine. Until this trial came out we didn't know if it was going to be clinically better or not and now we know it is better," said lead author Keipp Talbot, M.D., assistant professor of Medicine, who served as coordinating investigator for the more than 100 study sites.

"Older adults are the most vulnerable to influenza; they become the sickest and have the most hospitalizations. This vaccine works better than the standard dose and hence I would tell my patients to get the high-dose vaccine every year. In the meantime, we will continue to work to find newer and better vaccines for older adults."

Researchers concluded that the high-dose vaccine is safe, induces significantly higher antibody responses, and provides superior protection against laboratory-confirmed influenza illness compared to standard dose among persons over 65 years of age.

Study data also indicated that the high-dose vaccine may provide clinical benefit for the prevention of hospitalizations, pneumonia, cardio-respiratory conditions, non-routine medical visits, and medication use.

Between 1990 and 1999, seasonal influenza caused an average of 36,000 deaths and 226,000 hospitalizations per year in the U.S. Adults over 65 years old are particularly vulnerable to influenza complications, accounting for most seasonal influenza-related hospitalizations and deaths.

"Prevention of influenza should lower hospitalizations, deaths, heart attacks, and pneumonia," Talbot said. "This vaccine does have some more arm soreness than the usual vaccine because it is a higher dose. With this increased soreness comes greater protection."

Known as the Fluzone High-Dose vaccine, and made by Sanofi Pasteur, the inactivated influenza vaccine contains four times the amount of antigen that is contained in the standard-dose Fluzone vaccine.

"Fluzone High-Dose vaccine is the only influenza vaccine in the U.S. that is designed specifically to address the age-related decline of the immune system in older adults," said David P. Greenberg, M.D., vice president, Scientific & Medical Affairs, and chief medical officer, Sanofi Pasteur U.S.

Study authors said about one-in-four breakthrough cases of influenza could be prevented if the high-dose vaccine were used instead of the standard-dose vaccine.

"I see older adults hospitalized every year with influenza and many of them come into the hospital with pneumonias and heart failure because they had influenza," Talbot said "But I have to say our seniors in Nashville are very good at getting vaccinated. Locally they are very good and they do much better than their counterparts who are less than 65 years old. About 76 percent of this community of older adults are vaccinated for influenza each year."


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. The original article was written by Craig Boerner. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carlos A. DiazGranados, Andrew J. Dunning, Murray Kimmel, Daniel Kirby, John Treanor, Avi Collins, Richard Pollak, Janet Christoff, John Earl, Victoria Landolfi, Earl Martin, Sanjay Gurunathan, Richard Nathan, David P. Greenberg, Nadia G. Tornieporth, Michael D. Decker, H. Keipp Talbot. Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults. New England Journal of Medicine, 2014; 371 (7): 635 DOI: 10.1056/NEJMoa1315727

Cite This Page:

Vanderbilt University Medical Center. "High-dose flu vaccine more effective in elderly, study finds." ScienceDaily. ScienceDaily, 13 August 2014. <www.sciencedaily.com/releases/2014/08/140813173641.htm>.
Vanderbilt University Medical Center. (2014, August 13). High-dose flu vaccine more effective in elderly, study finds. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2014/08/140813173641.htm
Vanderbilt University Medical Center. "High-dose flu vaccine more effective in elderly, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/08/140813173641.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins