Featured Research

from universities, journals, and other organizations

Previous pulmonary disease linked to increased lung cancer risk in large study

Date:
August 15, 2014
Source:
American Thoracic Society (ATS)
Summary:
Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals. "The variations in the associations between lung cancer and different patterns of previous respiratory diseases that we observed in our study may indicate differences in the underlying etiological mechanisms," said the lead author. "Better understanding of these associations may help guide the type and frequency of clinical surveillance needed for patients with each of these diseases."

Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals.

Related Articles


"Associations between various respiratory diseases and lung cancer have been shown in earlier studies, but few of these studies considered multiple respiratory diseases simultaneously," said researcher Ann Olsson, PhD, of the International Agency for Research in Cancer in Lyon, France. "In our pooled analysis of seven case-control studies involving more than 12,500 cases and 14,900 controls, we found associations between lung cancer and chronic bronchitis, emphysema, and pneumonia, with a greater increased lung cancer risk among subjects with all three of these conditions."

The findings were published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Data on five previous respiratory diseases (chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma) were collected by self-report. Statistical analyses were adjusted for study center, age, employment in an occupation with an excess risk of lung cancer, level of education and detailed smoking habits.

Pneumonia and chronic bronchitis were the most frequently reported previous respiratory diseases. In analyses adjusting for other respiratory diseases and smoking, chronic bronchitis and emphysema were positively associated with lung cancer, with odds ratios among men of 1.33 (95% CI 1.20-1.48) for bronchitis and 1.50 (95% CI 1.21-1.87) for emphysema. A positive association was also found between pneumonia diagnosed two or fewer years prior and lung cancer (OR=3.31; CI 2.33-4.70 for men), Asthma had an inverse association with lung cancer risk, and no association was found between tuberculosis and lung cancer.

Patients with co-occurring chronic bronchitis, emphysema and pneumonia had a higher risk of lung cancer than those with chronic bronchitis only. There was no association between chronic bronchitis and lung cancer among patients with co-occurring asthma or tuberculosis.

"The variations in the associations between lung cancer and different patterns of previous respiratory diseases that we observed in our study may indicate differences in the underlying etiological mechanisms," said Dr. Olsson. "Better understanding of these associations may help guide the type and frequency of clinical surveillance needed for patients with each of these diseases."


Story Source:

The above story is based on materials provided by American Thoracic Society (ATS). Note: Materials may be edited for content and length.


Journal Reference:

  1. Rachel Denholm, Joachim Schüz, Kurt Straif, Isabelle Stücker, Karl-Heinz Jöckel, Darren R Brenner, Sara De Matteis, Paolo Boffetta, Florence Guida, Irene Brüske, Heinz-Erich Wichmann, Maria Teresa Landi, Neil Caporaso, Jack Siemiatycki, Wolfgang Ahrens, Hermann Pohlabeln, David Zaridze, John K Field, John McLaughlin, Paul Demers, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Benjamin Kendzia, Susan Peters, Thomas Behrens, Roel Vermeulen, Thomas Brüning, Hans Kromhout, Ann Olsson. Is Previous Respiratory Disease a Risk Factor for Lung Cancer? American Journal of Respiratory and Critical Care Medicine, 2014; 140723135313009 DOI: 10.1164/rccm.201402-0338OC

Cite This Page:

American Thoracic Society (ATS). "Previous pulmonary disease linked to increased lung cancer risk in large study." ScienceDaily. ScienceDaily, 15 August 2014. <www.sciencedaily.com/releases/2014/08/140815102035.htm>.
American Thoracic Society (ATS). (2014, August 15). Previous pulmonary disease linked to increased lung cancer risk in large study. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2014/08/140815102035.htm
American Thoracic Society (ATS). "Previous pulmonary disease linked to increased lung cancer risk in large study." ScienceDaily. www.sciencedaily.com/releases/2014/08/140815102035.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) — Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) — The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) — The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) — Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins