Featured Research

from universities, journals, and other organizations

Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research

Date:
August 21, 2014
Source:
University of Surrey
Summary:
Researchers have discovered how the receptors responsible for contractions in the bladder regulate the body's clock genes. The new study has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in aging bladders, demonstrating the importance of the clock in bladder physiology and aging.

Researchers at the University of Surrey have discovered how the receptors responsible for contractions in the bladder, regulate the body's clock genes.

Related Articles


The new study, published in The FASEB Journal, has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in aging bladders, demonstrating the importance of the clock in bladder physiology and aging.

While currently much is known about the central biological clock, little is known about the peripheral clocks in the body. This latest research challenges the long-held view that the central clock of the brain controls all the peripheral clocks in other parts of the body and that these in turn control the down-stream receptor molecules which generate specific cell activities, such as contraction, secretion and metabolism. However, researchers have found that receptors in the bladder, a muscular hollow organ in the body, exert control over the local clocks. The control of organ function via an interaction between the peripheral clocks and the receiving receptors is an important finding for understanding the pathology and development of new treatments for common diseases of the bladder, such as bladder overactivity and irritable bowel syndrome.

The team also believes the study will help advance understanding of how aging affects organ function in the body as the normal control of daily rhythms by the clock is weakened in aging tissue.

"Previously, people have believed that the brain 'master' clock controls the 'slave' peripheral clocks, but our study is the first to show that in a contractile organ, such as the bladder, its receptors also control these clocks," said lead author Dr Changhao Wu from the University of Surrey.

"By influencing the receptors in the bladder, we can also change our clock genes. These clocks are crucial in maintaining our physiological rhythm and preventing unwanted activities associated with an overactive bladder."


Story Source:

The above story is based on materials provided by University of Surrey. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Wu, G. Sui, S. N. Archer, P. Sassone-Corsi, K. Aitken, D. Bagli, Y. Chen. Local receptors as novel regulators for peripheral clock expression. The FASEB Journal, 2014; DOI: 10.1096/fj.13-243295

Cite This Page:

University of Surrey. "Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821161349.htm>.
University of Surrey. (2014, August 21). Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2014/08/140821161349.htm
University of Surrey. "Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821161349.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
Obamacare's Strange New Supreme Court Case

Obamacare's Strange New Supreme Court Case

Newsy (Mar. 4, 2015) President Obama&apos;s healthcare law is facing its second Supreme Court challenge, and it hinges on a single sentence. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins