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Tissue regeneration using anti-inflammatory nanomolecules

Date:
August 22, 2014
Source:
Children's Memorial Hospital
Summary:
Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. Now, researchers are working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction.

Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns. However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.

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The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.

More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications. Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.

This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant not just for bladder regeneration but for other types of tissue regeneration where foreign materials are utilized for structural support. I also envision the potential utility of these nanomolecules for the treatment of a wide range of dysfunctional inflammatory based conditions."


Story Source:

The above story is based on materials provided by Children's Memorial Hospital. Note: Materials may be edited for content and length.


Journal References:

  1. Matthew I. Bury, Natalie J. Fuller, Jay W. Meisner, Matthias D. Hofer, Matthew J. Webber, Lesley W. Chow, Sheba Prasad, Hatim Thaker, Xuan Yue, Vani S. Menon, Edward C. Diaz, Samuel I. Stupp, Earl Y. Cheng, Arun K. Sharma. The promotion of functional urinary bladder regeneration using anti-inflammatory nanofibers. Biomaterials, 2014; 35 (34): 9311 DOI: 10.1016/j.biomaterials.2014.07.057
  2. A. K. Sharma, M. I. Bury, N. J. Fuller, A. J. Marks, D. M. Kollhoff, M. V. Rao, P. V. Hota, D. J. Matoka, S. L. Edassery, H. Thaker, J. F. Sarwark, J. A. Janicki, G. A. Ameer, E. Y. Cheng. Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration. Proceedings of the National Academy of Sciences, 2013; 110 (10): 4003 DOI: 10.1073/pnas.1220764110

Cite This Page:

Children's Memorial Hospital. "Tissue regeneration using anti-inflammatory nanomolecules." ScienceDaily. ScienceDaily, 22 August 2014. <www.sciencedaily.com/releases/2014/08/140822124643.htm>.
Children's Memorial Hospital. (2014, August 22). Tissue regeneration using anti-inflammatory nanomolecules. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/08/140822124643.htm
Children's Memorial Hospital. "Tissue regeneration using anti-inflammatory nanomolecules." ScienceDaily. www.sciencedaily.com/releases/2014/08/140822124643.htm (accessed December 22, 2014).

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