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Baicalin suppresses iron accumulation after substantia nigra injury

Date:
August 27, 2014
Source:
Neural Regeneration Research
Summary:
Baicalin down-regulated iron concentration in a recent study, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.
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A growing number of studies have shown that excessive iron is closely associated with the pathogenesis of Parkinson's disease.

Previous studies from Chunyan Guo and co-workers from Capital Medical University in China have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson's disease rats. However, the relationship between iron concentration and transferrin expression is still unclear. Based on the previous findings, these scholars further explored the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson's disease rats.

Their findings published in the Neural Regeneration Research indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.


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The above post is reprinted from materials provided by Neural Regeneration Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chunyan Guo, Xin Chen, Pei Xiong. Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression. Neural Regeneration Research, 2014; 9 (6): 0 DOI: 10.4103/1673-5374.130108

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Neural Regeneration Research. "Baicalin suppresses iron accumulation after substantia nigra injury." ScienceDaily. ScienceDaily, 27 August 2014. <www.sciencedaily.com/releases/2014/08/140827101441.htm>.
Neural Regeneration Research. (2014, August 27). Baicalin suppresses iron accumulation after substantia nigra injury. ScienceDaily. Retrieved July 31, 2015 from www.sciencedaily.com/releases/2014/08/140827101441.htm
Neural Regeneration Research. "Baicalin suppresses iron accumulation after substantia nigra injury." ScienceDaily. www.sciencedaily.com/releases/2014/08/140827101441.htm (accessed July 31, 2015).

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