Featured Research

from universities, journals, and other organizations

Skin cells can be engineered into pulmonary valves for pediatric patients

Date:
September 2, 2014
Source:
Society of Thoracic Surgeons
Summary:
Researchers have found a way to take a pediatric patient’s skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve. It is estimated that nearly 800 patients per year could potentially benefit from bioengineered patient-specific pulmonary valves.

Researchers have found a way to take a pediatric patient's skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve. A proof of concept study in the September 2014 issue of The Annals of Thoracic Surgery provides more detail on this scientific development.

"Current valve replacements cannot grow with patients as they age, but the use of a patient-specific pulmonary valve would introduce a 'living' valvular construct that should grow with the patient. Our study is particularly important for pediatric patients who often require repeated operations for pulmonary valve replacements," said lead author David L. Simpson, PhD, from the University of Maryland School of Medicine in Baltimore.

Dr. Simpson, senior co-author Sunjay Kaushal, MD, PhD, and colleagues designed a process to transform skin cells from a simple biopsy into cells that become an important ingredient in a tissue-engineered pulmonary valve.

The pulmonary valve is a crescent-shaped valve that lies between the heart's right ventricle and pulmonary artery. It is responsible for moving blood from the heart into the lungs.

While the study was conducted in vitro (outside of the body), the next step will be implanting the new valves into patients to test their durability and longevity.

"We created a pulmonary valve that is unique to the individual patient and contains living cells from that patient. That valve is less likely to be destroyed by the patient's immune system, thus improving the outcome and hopefully increasing the quality of life for our patient," said Dr. Kaushal. "In the future, it may be possible to generate this pulmonary valve by using a blood sample instead of a skin biopsy."

Dr. Simpson added that he hopes the study will encourage additional research in tissue engineering and entice more people to enter the field, "Hopefully, growing interest and research in this field will translate more quickly into clinical application."

It is estimated that nearly 800 patients per year could potentially benefit from bioengineered patient-specific pulmonary valves, according to data from the STS Congenital Heart Surgery Database. The Database, which collects information from more than 95% of hospitals in the US and Canada that perform pediatric and congenital heart surgery, shows that approximately 3,200 patients underwent pulmonary valve replacement during a 4-year period from January 2010 to December 2013.


Story Source:

The above story is based on materials provided by Society of Thoracic Surgeons. Note: Materials may be edited for content and length.


Journal Reference:

  1. David L. Simpson, Brody Wehman, Yekaterina Galat, Sudhish Sharma, Rachana Mishra, Vasiliy Galat, Sunjay Kaushal. Engineering Patient-Specific Valves Using Stem Cells Generated From Skin Biopsy Specimens. The Annals of Thoracic Surgery, 2014; 98 (3): 947 DOI: 10.1016/j.athoracsur.2014.04.075

Cite This Page:

Society of Thoracic Surgeons. "Skin cells can be engineered into pulmonary valves for pediatric patients." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902092205.htm>.
Society of Thoracic Surgeons. (2014, September 2). Skin cells can be engineered into pulmonary valves for pediatric patients. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2014/09/140902092205.htm
Society of Thoracic Surgeons. "Skin cells can be engineered into pulmonary valves for pediatric patients." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902092205.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins