Featured Research

from universities, journals, and other organizations

Risk of diabetes in children, adolescents exposed to antipsychotics: Danish 12-year case-control study

Date:
September 2, 2014
Source:
Elsevier
Summary:
Children and adolescents pegged with a psychiatric diagnosis had an increased risk of developing diabetes if they were exposed to antipsychotics. Using data from the nationwide Danish registers, a group of researchers studied 48,299 children and adolescents with psychiatric disorders to document the frequency and possible predictors of type II diabetes, defined by treatment with an oral antidiabetic drug.

A study published in the September 2014 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that children and adolescents diagnosed with a psychiatric diagnosis had an increased risk of developing diabetes if they were exposed to antipsychotics.

Using data from the nationwide Danish registers, a group of researchers led by Dr. Renι Ernst Nielsen, Psychiatry, Aalborg University Hospital, Denmark, studied 48,299 children and adolescents with psychiatric disorders to document the frequency and possible predictors of type II diabetes, defined by treatment with an oral antidiabetic drug.

The study found that the absolute risk of diabetes in psychiatrically ill youth exposed to antipsychotic medications was approximately 0.72% compared to 0.27% in those not exposed to antipsychotics. Especially female sex and antipsychotic drug exposure increased the risk of developing type II diabetes, while type of psychiatric diagnosis was not related to diabetes development.

Taken together, these data raise further concern about the frequent use of antipsychotics for non-psychotic disorders and off-label conditions, such as disruptive behavior disorders, which should first be treated with non-pharmacologic management options. Moreover, regular cardiometabolic monitoring, including fasting glucose and hemoglobin A1C testing should be integral part of antipsychotic prescribing to children and adolescents.

Dr. Nielsen said of the study, "The use of antipsychotic drug treatment can be necessary for some of the psychiatric disorders diagnosed in children and adolescents. This study underscores the importance of following the current guidelines that antipsychotics should only be used in children and adolescents when other evidence-based and safer treatment options have been exhausted."

The study was a longitudinal register linkage case control study of type II diabetes, defined as prescription of an oral antidiabetic drug, in all child and adolescent hospital-based psychiatric patients diagnosed in Denmark from January 1st 1999 and June 30st 2010. The time period was defined to allow full retrieval of data from all relevant registers.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Renι Ernst Nielsen, Mathilde Frahm Laursen, Ditte Lammers Vernal, Charlotte Bisgaard, Helle Jakobsen, Hans-Christoph Steinhausen, Christoph U. Correll. Risk of Diabetes in Children and Adolescents Exposed to Antipsychotics: A Nationwide 12-Year Case-Control Study. Journal of the American Academy of Child & Adolescent Psychiatry, 2014; 53 (9): 971 DOI: 10.1016/j.jaac.2014.04.023

Cite This Page:

Elsevier. "Risk of diabetes in children, adolescents exposed to antipsychotics: Danish 12-year case-control study." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902093210.htm>.
Elsevier. (2014, September 2). Risk of diabetes in children, adolescents exposed to antipsychotics: Danish 12-year case-control study. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/09/140902093210.htm
Elsevier. "Risk of diabetes in children, adolescents exposed to antipsychotics: Danish 12-year case-control study." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902093210.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins