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New figures on two muscular dystrophy disorders

Date:
February 16, 2015
Source:
University of Iowa
Summary:
Public health researchers report the freqency of two muscle-weakness disorders that strike mostly boys: Duchenne muscular dystrophy and Becker muscular dystrophy. The team found that about 1 in 5,000 boys in the United States, between 5 and 9 years old, have the inherited disorders. They also find that the diseases appear to affect Hispanic boys more often than white or African-American boys, for unknown reasons.
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FULL STORY

Researchers in public health have reported in the first broad study in the United States the frequency of two muscle-weakness disorders that strike mostly boys: Duchenne muscular dystrophy and Becker muscular dystrophy.

The research team, led by the University of Iowa, found that about 1 in 5,000 boys, between 5 and 9 years old, have the inherited disorders. They also find the diseases appear to affect Hispanic boys more often than white or African-American boys, for reasons that are not well understood.

The findings are important, because they give a better understanding of the number of children and families affected by the disorders. They also give doctors and health-care professionals valuable information, so they can better plan to care for those affected, especially as the diseases progress.

"There were always some rather crude estimates of how common these muscular dystrophies are," says Paul Romitti, an epidemiologist at the UI and corresponding author of the study, published online in the journal Pediatrics. "It tells us that they're still an important public health concern."

Muscular dystrophies are a group of genetic disorders that result in muscle weakness over time. The most common muscular dystrophy in children is Duchenne muscular dystrophy, which predominantly affects males. Historically, Duchenne has resulted in loss of walking ability between ages 7 and 13 years, and death in the teens or 20s. Becker muscular dystrophy is similar to Duchenne, but has later onset and slower, more variable progression of symptoms. There is no cure for either disorder.

In the population-based study, researchers analyzed data -- culled mostly from birth and death certificates and medical records -- for children born between 1982 and 2011 in six states: Arizona, Colorado, Georgia, Hawaii, Iowa and western New York. They calculated the disorders' prevalence across four five-year time periods, beginning in the 1991-1995 period and ending in 2006-2010.

The U.S. Centers for Disease Control funded the work, through the Muscular Dystrophy Surveillance, Research and Tracking Network, or MD STARnet.

The team found the disorders in roughly 2 per 10,000 boys in the 1991-1995, 1996-2000 and 2001-2005 periods. In 2006-2010, the prevalence was 1.5, but the researchers believe the lower figure could be due to delayed diagnosis, among other factors.

Hispanic youth had a higher prevalence in all but the last time period, while African-American children were least likely to be affected for all time periods.

Three-quarters of the 845 total cases were Duchenne, according to the study.

The frequency across the time periods is roughly the same as found in a MD STARnet study, in four states and reported in 2007, and from a study done in Colorado in 1974, according to the paper.

Despite their rarity, the researchers say medical professionals should be prepared.

"People who have these disorders require daily attention from their families and complex-care management from health-care providers," says Romitti, professor in the UI College of Public Health. "The new data will help to estimate the cost for the parents and the health-care system. We are continuing to learn more about the total impact of these disorders on the child and the family."

Contributing authors include: Yong Zhu, former post-doctoral researcher at the UI; Soman Puzhankara, with the UI College of Public Health; Katherine James, at the University of Colorado-Aurora; Sarah Nabukera, former post-doctoral researcher at the UI; Gideon Zamba, associate professor in biostatistics at the UI; Emma Ciafaloni, at the University of Rochester; Christopher Cunniff, at the University of Arizona; Charlotte Druschel, at the New York State Department of Health and State University of New York system; Katherine Mathews, pediatrics professor at the UI; Dennis Matthews, University of Colorado-Aurora; John Meaney, University of Arizona; Jennifer Andrews, University of Arizona; Kristin Caspers Conway, associate research scientist at the UI; Deborah Fox, New York State Department of Health; Natalie Street, Melissa Adams and Julie Bolen at the Centers for Disease Control and Prevention.


Story Source:

Materials provided by University of Iowa. Original written by Richard C. Lewis. Note: Content may be edited for style and length.


Journal Reference:

  1. Paul A. Romitti, Yong Zhu, Soman Puzhankara, Katherine A. James, Sarah K. Nabukera, Gideon K.D. Zamba, Emma Ciafaloni, Christopher Cunniff, Charlotte M. Druschel, Katherine D. Mathews, Dennis J. Matthews, F. John Meaney, Jennifer G. Andrews, Kristin M. Caspers Conway, Deborah J. Fox, Natalie Street, Melissa M. Adams, and Julie Bolen , on behalf of the MD STARnet. Prevalence of Duchenne and Becker Muscular Dystrophies in the United States. Pediatrics, February 16, 2015 DOI: 10.1542/peds.2014-2044

Cite This Page:

University of Iowa. "New figures on two muscular dystrophy disorders." ScienceDaily. ScienceDaily, 16 February 2015. <www.sciencedaily.com/releases/2015/02/150216064630.htm>.
University of Iowa. (2015, February 16). New figures on two muscular dystrophy disorders. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2015/02/150216064630.htm
University of Iowa. "New figures on two muscular dystrophy disorders." ScienceDaily. www.sciencedaily.com/releases/2015/02/150216064630.htm (accessed March 28, 2024).

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