Featured Research

from universities, journals, and other organizations

Gene For Inherited Syndrome Is Possible New Tumor Suppressor

Date:
February 2, 1998
Source:
Ohio State University
Summary:
New research has found the gene responsible for a rare inherited disorder that can lead to cancer in many different organs. Unexpectedly, the work might also have uncovered a new category of tumor suppressor genes.

COLUMBUS, Ohio -- New research has found the gene responsible for a rare inherited disorder that can lead to cancer in many different organs. Unexpectedly, the work might also have uncovered a new category of tumor suppressor genes.

The disorder is Peutz-Jeghers syndrome (PJS). People who are born with it typically develop precancerous polyps in the intestines in their teen years or later, and have freckle-like spots on the lips, around the mouth, and on the fingers.

These individuals are also at a higher risk for a variety of cancers, including those of the intestine, breast, pancreas, testis, and ovary, said Albert de la Chapelle, director of the Human Cancer Genetics Program at Ohio State University's Comprehensive Cancer Center and a co-author of the study.

The research, published this month in the journal Nature, will likely lead to a test that can be used to unequivocally diagnosis individuals with PJS and detect family members who carry the gene.

In addition, it may lead to a better understanding of how some cancers happen. "The more difficult, but in many ways more interesting, part of this story relates to how changes in this gene lead to cancer," said de la Chapelle.

"This is the way things often go when you're looking for genes. You begin with a condition, and you have no idea what sort of a gene causes it. So you map the gene's location on a chromosome and clone it, and then you find out what it does. Quite often, the function of the gene is very surprising."

In this study, de la Chapelle was a member of a team of researchers who studied 12 individuals with PJS. By examining cells from polyps removed from a single patient, the researchers were able to map the location of the gene to one tip of chromosome 19 (more specifically, to the tip of the short arm of chromosome 19).

With the gene identified, further study revealed a number of mutations that disabled it.

A gene that leads to cancer when it is disabled is known as a tumor suppressor gene. Tumor suppressor genes work by producing a protein that helps prevent run- away cell division. If the gene is damaged and the protein doesn't work properly, uncontrolled cell proliferation -- and cancer -- can occur.

Initially, de la Chapelle and the other members of the research team had no idea what kind of protein the undamaged PJS gene produced, or what role that protein played in the cell.

But by comparing the structure of the PJS gene with already-known genes, they were startled to find that the PJS gene produces a type of enzyme known as a protein kinase.

"This surprised us," said de la Chapelle. "As far as we know, this is the first time a protein kinase gene has been identified as a tumor suppressor gene."

Cells have genes for many types of protein kinase enzymes, and some of these enzymes do play a role in causing cancer. But in those cases, cancer rises because the genes produce too much of the enzyme.

In PJS, on the other hand, cancer seems to occur because a protein kinase isn't produced.

"As of now," said de la Chapelle, "we have no clue as to how the loss of this gene might lead to cancer. That work will require many experiments to learn what other proteins this protein interacts with and how this particular gene might fit into one of the cancer-producing pathways."

"The intriguing thing here is that this unusual disorder is characterized by the occurrence of polyps in the intestine that are often premalignant, and by the presence of peculiar freckle-like spots on the lips and the skin around the mouth and on the fingers. How these two relate to each other is absolutely unknown."

Furthermore, he said, "the combination of tumors that can occur with this syndrome really gives no clue to what's going on. That is truly intriguing."

The work on PJS continues in de la Chapelle's laboratory with studies he hopes will reveal how mutations in the PJS gene predispose an individual to cancer.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Gene For Inherited Syndrome Is Possible New Tumor Suppressor." ScienceDaily. ScienceDaily, 2 February 1998. <www.sciencedaily.com/releases/1998/02/980202020430.htm>.
Ohio State University. (1998, February 2). Gene For Inherited Syndrome Is Possible New Tumor Suppressor. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/1998/02/980202020430.htm
Ohio State University. "Gene For Inherited Syndrome Is Possible New Tumor Suppressor." ScienceDaily. www.sciencedaily.com/releases/1998/02/980202020430.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins