Featured Research

from universities, journals, and other organizations

Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer

Date:
March 4, 1998
Source:
Wistar Institute
Summary:
Scientists at The Wistar Institute, working in collaboration with researchers from around the world, have identified a new gene, called BAP1, associated with breast and lung cancer development. The group's findings may have major implications for the treatment of breast and lung cancers.

Philadelphia, PA, March 1, 1998 -- Scientists at The Wistar Institute, working in collaboration with researchers from around the world, have identified a new gene, called BAP1, associated with breast and lung cancer development. The group's findings, which may have major implications for the treatment of breast and lung cancers, appear in today's issue of Oncogene.

BAP1, discovered in the Wistar laboratory of Dr. Frank J. Rauscher III, encodes an enzyme that helps to regulate levels of BRCA1, a gene known to cause hereditary breast and ovarian cancers.

Three years ago, scientists in Utah identified the BRCA1 gene, which was a landmark accomplishment in cancer research. The discovery of BRCA1 made it possible to genetically test for carriers of the gene. When a faulty BRCA1 gene is inherited, a woman's chances of developing breast and/or ovarian cancer are greater than 80 percent during her lifetime.

Since BRCA1's discovery, scientists around the world have been working feverishly to discover the functions of the BRCA1 protein. Proteins, the main ingredients in cells, have shapes and functions that are genetically defined.

With a clear understanding of the role BRCA1 plays in normal breast development, scientists can better explain how mutations of the BRCA1 gene might alter that process. Laboratory studies have revealed that BRCA1 and BAP1 form a complex in the cell that controls BRCA1's activities, including its deterioration.

The Wistar investigators have also learned that, like BRCA1, the BAP1 gene is a cancer gene. Mutations of BAP1 have been found in non-small-cell lung cancers.

BAP1 and BRCA1 are both tumor suppressor gene products that appear to be part of a large complex that controls the growth of breast and lung epithelial cells. Mutations in either BAP1 or BRCA1 abolish this complex and lead to the development of cancer.

The discovery of BAP1 makes it possible to do genetic testing for its presence, making it a potential target for drugs that combat breast and lung cancers.

The team of Wistar scientists who conducted the research on BAP1 includes Drs. Frank J. Rauscher III, David E. Jensen, Alexander M. Ishov, David C. Schultz, Gerd G. Maul, Nickolai Barlev, Shelley L. Berger and George C. Prendergast. Collaborating scientists are from the Hamon Center for Therapeutic Oncology Research at the University of Texas Southwestern Medical Center; the John F. Kennedy Institute and The Department of Medical Genetics at The Panum Institute, Copenhagen, Denmark; the Department of Molecular Genetics, Novo Nordisk, Bagsvaerd, Denmark; the Department of Biochemistry, Emory University, Atlanta, Georgia; the Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine.

Funding for this Wistar research has been provided, in part, by the Susan G. Koman Breast Cancer Foundation. Other support has come from the National Institutes of Health, Pew Scholars Program in the Biomedical Sciences, Irving A. Hansen Memorial Foundation, Mary A. Rumsey Memorial Foundation, Danish Cancer Society, Charles E. Culpepper Foundation, American Cancer Society and National Cancer Institute.

The Wistar Institute, established in 1892, was the first independent medical research facility in the country. For more than 100 years, Wistar scientists have been making history and improving world health through their development of vaccines for diseases that include rabies, German measles, infantile gastroenteritis (rotavirus), and cytomegalovirus; discovery of molecules like interleukin-12, which are helping the immune system fight bacteria, parasites, viruses and cancer; and location of genes that contribute to the development of diseases like breast, lung and prostate cancer. Wistar is a National Cancer Institute Cancer Center.


Story Source:

The above story is based on materials provided by Wistar Institute. Note: Materials may be edited for content and length.


Cite This Page:

Wistar Institute. "Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer." ScienceDaily. ScienceDaily, 4 March 1998. <www.sciencedaily.com/releases/1998/03/980304073836.htm>.
Wistar Institute. (1998, March 4). Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/1998/03/980304073836.htm
Wistar Institute. "Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/1998/03/980304073836.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Beijing Marathon Runners Brave Hazardous Air Pollution

Beijing Marathon Runners Brave Hazardous Air Pollution

AFP (Oct. 19, 2014) Tens of thousands of runners battled thick smog at the Beijing Marathon on Sunday, with some donning masks as the levels of PM2.5 small pollutant particles soared to 16 times the maximum recommended level. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins